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Literature summary extracted from
- Aminopeptidase A (2004), Handbook of Proteolytic Enzymes (2nd Edition), 1, 299-303.
No PubMed abstract available
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.11.7 | BP-1/6C3 antigen, gene ENPEP, full-length DNA and amino acid sequence determination and analysis, genetic structure, determination of 5'-flanking regions, promoter sequence, and DNA-binding motifs for transcription factors, overview, transient or stable expression of recombinant enzyme with transmembrane regions or cytoplasmic regions by human interleukin 4 leader sequence in COS-7 cells | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.7 | 1,10-phenanthroline | - |
Mus musculus |  |
| 3.4.11.7 | Cd2+ | complete inhibition at 1 mM | Mus musculus | |
| 3.4.11.7 | Cu2+ | complete inhibition at 1 mM | Mus musculus | |
| 3.4.11.7 | EC33 | specific inhibition | Mus musculus | |
| 3.4.11.7 | EDTA | - |
Mus musculus | |
| 3.4.11.7 | EGTA | - |
Mus musculus | |
| 3.4.11.7 | Hg2+ | complete inhibition at 1 mM | Mus musculus | |
| 3.4.11.7 | Ni2+ | complete inhibition at 1 mM | Mus musculus | |
| 3.4.11.7 | RB150 | selective and specific prodrug of the enzyme inhibitor EC33, inhibits the enzyme given i.v. to rats | Mus musculus | |
| 3.4.11.7 | Zn2+ | complete inhibition at 1 mM | Mus musculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.11.7 | cytoplasm | the enzyme has cytosolic and transmembrane regions | Mus musculus | 5737 | - |
| 3.4.11.7 | membrane | the enzyme has cytosolic and transmembrane regions | Mus musculus | 16020 | - |
| 3.4.11.21 | cytoplasm | - |
Mus musculus | 5737 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.7 | Ca2+ | activates | Mus musculus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.7 | 45000 | 400000 | dependent on the tissue source and purification method | Mus musculus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.7 | additional information | Mus musculus | the enzyme is involved in angiotensin metabolism | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.11.7 | Mus musculus | P16406 | - |
- |
| 3.4.11.21 | Mus musculus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.11.7 | recombinant enzyme from COS-7 cells by BP-1 antibody affinity chromatography | Mus musculus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.11.7 | brain | - |
Mus musculus | - |
| 3.4.11.7 | enterocyte | intestinal, brush border | Mus musculus | - |
| 3.4.11.7 | hypothalamus | - |
Mus musculus | - |
| 3.4.11.7 | kidney | brush border | Mus musculus | - |
| 3.4.11.7 | additional information | broad tissue distribution | Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.7 | additional information | the enzyme is involved in angiotensin metabolism | Mus musculus | ? | - |
? | |
| 3.4.11.7 | additional information | the enzyme catalyzes the hydrolysis of N-(alpha-L-glutamyl)- moieties more efficiently than the hydrolysis of alpha-L-aspartyl derivatives | Mus musculus | ? | - |
? | |
| 3.4.11.7 | N-(alpha-L-glutamyl)-4-nitroanilide + H2O | - |
Mus musculus | L-glutamic acid + 4-nitroaniline | - |
? | |
| 3.4.11.7 | N-(alpha-L-glutamyl)-beta-naphthylamide + H2O | - |
Mus musculus | L-glutamic acid + beta-naphthylamine | - |
? | |
| 3.4.11.21 | additional information | the enzyme catalyzes the hydrolysis of N-terminal alpha-L-glutamyl and alpha-L-aspartyl residues | Mus musculus | ? | - |
? | |
| 3.4.11.21 | N-(alpha-L-glutamyl)-2-naphthylamide + H2O | - |
Mus musculus | L-glutamic acid + 2-naphthylamine | - |
? | |
| 3.4.11.21 | N-(alpha-L-glutamyl)-4-nitroanilide + H2O | - |
Mus musculus | L-glutamic acid + 4-nitroaniline | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.11.7 | acidic alpha-aminopeptidase | - |
Mus musculus |
| 3.4.11.7 | aminopeptidase A | - |
Mus musculus |
| 3.4.11.7 | angiotensinase A | - |
Mus musculus |
| 3.4.11.7 | APA | - |
Mus musculus |
| 3.4.11.7 | aspartate aminopeptidase | - |
Mus musculus |
| 3.4.11.7 | BP-1/6C3 antigen | - |
Mus musculus |
| 3.4.11.7 | Ca2+-activated glutamate aminopeptidase | - |
Mus musculus |
| 3.4.11.7 | EAP | - |
Mus musculus |
| 3.4.11.7 | glutamyl aminopeptidase | - |
Mus musculus |
| 3.4.11.7 | membrane aminopeptidase II | - |
Mus musculus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.7 | 37 | - |
assay at | Mus musculus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.7 | 7.2 | - |
approximately | Mus musculus |
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Release 2023.1 (January 2023)
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