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Literature summary extracted from

  • Dou, X.; Wu, D.; An, W.; Davies, J.; Hashmi, S.B.; Ukil, L.; Osmani, S.A.
    The PHOA and PHOB cyclin-dependent kinases perform an essential function in Aspergillus nidulans (2003), Genetics, 165, 1105-1115.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.22 genes phoA and phoB, DNA and amino acid sequence determination and analysis Aspergillus nidulans

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.22 K39R site-directed mutagenesis, negative dominant kinase inactive mutant of PHOA, mutant strain shows defects in cell cycle and nuclear division Aspergillus nidulans
2.7.11.22 additional information construction of PHOA and PHOB null mutant strains, deletion of PHOB causes no phenotype, while deletion of PHOA inhibits growth, a double null mutant shows defects in cell cycle and nuclear division and is lethal, overview, complementation of the double null mutant with expression of human CDK5 Aspergillus nidulans

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.22 34000
-
 x * 34000, PHOB, SDS-PAGE Aspergillus nidulans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.22 additional information Aspergillus nidulans the CDKs PHOA is involved in modulation of differentiation in response to environmental conditions, including limited phosphorous, but does not play an essential role in regulation of phosphorous aquisition ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.22 Aspergillus nidulans
-
 several strains
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.22 additional information the CDKs PHOA is involved in modulation of differentiation in response to environmental conditions, including limited phosphorous, but does not play an essential role in regulation of phosphorous aquisition Aspergillus nidulans ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.22 ? x * 34000, PHOB, SDS-PAGE Aspergillus nidulans

Synonyms

EC Number Synonyms Comment Organism
2.7.11.22 CDK
-
 Aspergillus nidulans
2.7.11.22 PHOA
-
 Aspergillus nidulans
2.7.11.22 PHOB
-
 Aspergillus nidulans

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.22 ATP
-
 Aspergillus nidulans