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Literature summary extracted from
- The structural comparison of the bacterial PepX and human DPP-IV reveals sites for the design of inhibitors of PepX activity (2005), FEBS J., 272, 2050-2059.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.14.11 | Diprotin A | IC50: 0.26 mM | Lactococcus lactis |  |
| 3.4.14.11 | Diprotin B | IC50: 0.6 mM | Lactococcus lactis | |
| 3.4.14.11 | Val-pyrrolidide | IC50: 0.03 mM | Lactococcus lactis | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.14.11 | Lactococcus lactis | P22346 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.14.11 | Ala-Pro-4-nitroanilide + H2O | - |
Lactococcus lactis | Ala-Pro + 4-nitroaniline | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.14.11 | PepX | - |
Lactococcus lactis |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.14.11 | 8.5 | - |
- |
Lactococcus lactis |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.14.11 | 0.03 | - |
IC50: 0.03 mM | Lactococcus lactis | Val-pyrrolidide | |
| 3.4.14.11 | 0.26 | - |
IC50: 0.26 mM | Lactococcus lactis | Diprotin A | |
| 3.4.14.11 | 0.6 | - |
IC50: 0.6 mM | Lactococcus lactis | Diprotin B | |
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