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Literature summary extracted from
- Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase (2002), Eur. Respir. J., 19, 1136-1141.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.37 | colistin | significant stimulation of purified elastase and elastase activity in sputum samples, able to reverse inhibition by heparin | Homo sapiens |  |
| 3.4.21.37 | erythromycin | significant stimulation of purified elastase | Homo sapiens | |
| 3.4.24.26 | colistin | - |
Pseudomonas aeruginosa | |
| 3.4.24.26 | erythromycin | - |
Pseudomonas aeruginosa | |
| 3.4.24.26 | additional information | no stimulation by ceftazidime and gentamycin | Pseudomonas aeruginosa | |
| 3.4.24.26 | tobramycin | - |
Pseudomonas aeruginosa | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.37 | alpha1-antitrypsin | very potent inhibitor, complete inhibition at nanomolar concentrations, colistin is unable to reverse inhibition | Homo sapiens | |
| 3.4.21.37 | ceftazidime | slight inhibition of purified elastase | Homo sapiens | |
| 3.4.21.37 | gentamycin | slight inhibition of purified elastase | Homo sapiens | |
| 3.4.21.37 | heparin | strong inhibition, partly reversible by addition of colistin | Homo sapiens | |
| 3.4.21.37 | N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone | complete inhibition at low micromolar concentrations, colistin is unable to reverse the complete inhibition with 0.005 mM but able to reverse the partial inhibition with 0.0005 mM N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone | Homo sapiens | |
| 3.4.21.37 | tobramycin | slight inhibition of purified elastase | Homo sapiens | |
| 3.4.24.26 | phosphoramidon | - |
Pseudomonas aeruginosa | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.37 | Elastin + H2O | Homo sapiens | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged | ? | protein cleaved at at least one location | ? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.37 | Homo sapiens | - |
patients with cystic fibrosis | - |
| 3.4.24.26 | Pseudomonas aeruginosa | P14756 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.37 | lung | - |
Homo sapiens | - |
| 3.4.21.37 | neutrophil | - |
Homo sapiens | - |
| 3.4.21.37 | sputum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.37 | Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | Elastin + H2O | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged | Homo sapiens | ? | protein cleaved at at least one location | ? | |
| 3.4.21.37 | methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Homo sapiens | methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? | |
| 3.4.24.26 | BODIPY-casein + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.26 | PE | - |
Pseudomonas aeruginosa |
| 3.4.24.26 | Pseudomonas aeruginosa elastase | - |
Pseudomonas aeruginosa |
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