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Literature summary extracted from

  • Cuevas, I.C.; Rohloff, P.; Sanchez, D.O.; Docampo, R.
    Characterization of farnesylated protein tyrosine phosphatase TcPRL-1 from Trypanosoma cruzi (2005), Eukaryot. Cell, 4, 1550-1561.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.48 additional information mutantv enzyme lacking C-terminal CAAX motif localizes to the cytoplasm Trypanosoma cruzi

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 additional information not inhibitory: pentamidine, okadaic acid, sodium fluoride up to 5 mM, EDTA up to 10 mM Trypanosoma cruzi
3.1.3.48 orthovanadate 50% inhibition at 0.075 mM Trypanosoma cruzi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.48 0.0008
-
 4-nitrophenyl phosphate pH 7.5 Trypanosoma cruzi

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.48 21000
-
 x * 21000, SDS-PAGE Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Trypanosoma cruzi Q6JHV2 isoform PRL-1
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.48 additional information enzyme is farnesylated Trypanosoma cruzi

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.48 amastigote within the endocytic pathway Trypanosoma cruzi
-
3.1.3.48 epimastigote within the endocytic pathway Trypanosoma cruzi
-
3.1.3.48 trypomastigote within the endocytic pathway Trypanosoma cruzi
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 4-nitrophenyl phosphate + H2O
-
 Trypanosoma cruzi 4-nitrophenol + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.48 ? x * 21000, SDS-PAGE Trypanosoma cruzi

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 PRL-1
-
 Trypanosoma cruzi

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.48 7.5 8
-
 Trypanosoma cruzi