EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.25 | additional information | polymerization and phosphorylation activates the enzyme after dissociation of thioredoxin due to TNF-alpha treatment | Mus musculus | |
2.7.11.25 | additional information | polymerization and phosphorylation activates the enzyme after dissociation of thioredoxin due to TNF-alpha treatment | Homo sapiens | |
2.7.11.25 | reactive oxygene species | the enzyme is oxidative stress-induced | Mus musculus | |
2.7.11.25 | reactive oxygene species | the enzyme is oxidative stress-induced | Homo sapiens | |
2.7.11.25 | TNF-alpha | treatment with TNF-alpha dissociates the inhibitor thioredoxin from the enzyme's N-terminus | Mus musculus | |
2.7.11.25 | TNF-alpha | treatment with TNF-alpha dissociates the inhibitor thioredoxin from the enzyme's N-terminus | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.25 | thioredoxin | the reduced form binds to the N-terminus | Homo sapiens | |
2.7.11.25 | thioredoxin | the reduced form binds to the N-terminus | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.25 | ATP + MKK3 | Mus musculus | activation of the p38 MAP kinase signaling pathway leading to apoptosis | ADP + phosphorylated MKK3 | - |
? | |
2.7.11.25 | ATP + MKK3 | Homo sapiens | activation of the p38 MAP kinase signaling pathway leading to apoptosis | ADP + phosphorylated MKK3 | - |
? | |
2.7.11.25 | ATP + MKK4 | Mus musculus | activation of the Jun N-terminal kinase, JNK, pathway leading to apoptosis | ADP + phosphorylated MKK4 | - |
? | |
2.7.11.25 | ATP + MKK4 | Homo sapiens | activation of the Jun N-terminal kinase, JNK, pathway leading to apoptosis | ADP + phosphorylated MKK4 | - |
? | |
2.7.11.25 | ATP + MKK6 | Mus musculus | activation of the p38 MAP kinase signaling pathway leading to apoptosis | ADP + phosphorylated MKK6 | - |
? | |
2.7.11.25 | ATP + MKK6 | Homo sapiens | activation of the p38 MAP kinase signaling pathway leading to apoptosis | ADP + phosphorylated MKK6 | - |
? | |
2.7.11.25 | ATP + MKK7 | Mus musculus | activation of the Jun N-terminal kinase, JNK, signaling pathway leading to apoptosis | ADP + phosphorylated MKK7 | - |
? | |
2.7.11.25 | ATP + MKK7 | Homo sapiens | activation of the Jun N-terminal kinase, JNK, signaling pathway leading to apoptosis | ADP + phosphorylated MKK7 | - |
? | |
2.7.11.25 | additional information | Mus musculus | activation mechanism of ASK1, overview, ASK1 is involved in oxidative stress-induced cell death and adaptation processes to various stresses, the enzyme is required for induction of apoptosis by e.g. Fas or TNF-alpha, or by the endoplasmic reticulum, mechanism | ? | - |
? | |
2.7.11.25 | additional information | Homo sapiens | activation mechanism of ASK1, overview, ASK1 is involved in oxidative stress-induced cell death and adaptation processes to various stresses, the enzyme is required for induction of apoptosis by e.g. Fas or TNF-alpha, or by the endoplasmic reticulum, mechanism, ASK1 plays an important role in neuropathological alterations in polyQ diseases | ? | - |
? | |
2.7.11.25 | additional information | Caenorhabditis elegans | NSY-1 functions in the control of asymmetric expression of odor receptor gene str-2, odor discrimination, and odor chemotaxis, thus possibly in functional differentiation of the nervous system, the enzyme functions downstream of UNC-43 CaMKII | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.25 | Caenorhabditis elegans | - |
- |
- |
2.7.11.25 | Homo sapiens | - |
- |
- |
2.7.11.25 | Mus musculus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.11.25 | phosphoprotein | phosphorylation activates the enzyme | Mus musculus |
2.7.11.25 | phosphoprotein | phosphorylation activates the enzyme | Homo sapiens |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.7.11.25 | ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate | mechanism of ASK1 | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.25 | brain | - |
Mus musculus | - |
2.7.11.25 | brain | - |
Homo sapiens | - |
2.7.11.25 | neuron | - |
Mus musculus | - |
2.7.11.25 | neuron | - |
Homo sapiens | - |
2.7.11.25 | olfactory neuron | - |
Caenorhabditis elegans | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.25 | ATP + MKK3 | a MAPKK | Mus musculus | ADP + phosphorylated MKK3 | - |
? | |
2.7.11.25 | ATP + MKK3 | a MAPKK | Homo sapiens | ADP + phosphorylated MKK3 | - |
? | |
2.7.11.25 | ATP + MKK3 | activation of the p38 MAP kinase signaling pathway leading to apoptosis | Mus musculus | ADP + phosphorylated MKK3 | - |
? | |
2.7.11.25 | ATP + MKK3 | activation of the p38 MAP kinase signaling pathway leading to apoptosis | Homo sapiens | ADP + phosphorylated MKK3 | - |
? | |
2.7.11.25 | ATP + MKK4 | activation of the Jun N-terminal kinase, JNK, pathway leading to apoptosis | Mus musculus | ADP + phosphorylated MKK4 | - |
? | |
2.7.11.25 | ATP + MKK4 | activation of the Jun N-terminal kinase, JNK, pathway leading to apoptosis | Homo sapiens | ADP + phosphorylated MKK4 | - |
? | |
2.7.11.25 | ATP + MKK4 | i.e. SEK1, a MAPKK | Mus musculus | ADP + phosphorylated MKK4 | - |
? | |
2.7.11.25 | ATP + MKK4 | i.e. SEK1, a MAPKK | Homo sapiens | ADP + phosphorylated MKK4 | - |
? | |
2.7.11.25 | ATP + MKK6 | a MAPKK | Mus musculus | ADP + phosphorylated MKK6 | - |
? | |
2.7.11.25 | ATP + MKK6 | a MAPKK | Homo sapiens | ADP + phosphorylated MKK6 | - |
? | |
2.7.11.25 | ATP + MKK6 | activation of the p38 MAP kinase signaling pathway leading to apoptosis | Mus musculus | ADP + phosphorylated MKK6 | - |
? | |
2.7.11.25 | ATP + MKK6 | activation of the p38 MAP kinase signaling pathway leading to apoptosis | Homo sapiens | ADP + phosphorylated MKK6 | - |
? | |
2.7.11.25 | ATP + MKK7 | a MAPKK | Mus musculus | ADP + phosphorylated MKK7 | - |
? | |
2.7.11.25 | ATP + MKK7 | a MAPKK | Homo sapiens | ADP + phosphorylated MKK7 | - |
? | |
2.7.11.25 | ATP + MKK7 | activation of the Jun N-terminal kinase, JNK, signaling pathway leading to apoptosis | Mus musculus | ADP + phosphorylated MKK7 | - |
? | |
2.7.11.25 | ATP + MKK7 | activation of the Jun N-terminal kinase, JNK, signaling pathway leading to apoptosis | Homo sapiens | ADP + phosphorylated MKK7 | - |
? | |
2.7.11.25 | additional information | activation mechanism of ASK1, overview, ASK1 is involved in oxidative stress-induced cell death and adaptation processes to various stresses, the enzyme is required for induction of apoptosis by e.g. Fas or TNF-alpha, or by the endoplasmic reticulum, mechanism | Mus musculus | ? | - |
? | |
2.7.11.25 | additional information | activation mechanism of ASK1, overview, ASK1 is involved in oxidative stress-induced cell death and adaptation processes to various stresses, the enzyme is required for induction of apoptosis by e.g. Fas or TNF-alpha, or by the endoplasmic reticulum, mechanism, ASK1 plays an important role in neuropathological alterations in polyQ diseases | Homo sapiens | ? | - |
? | |
2.7.11.25 | additional information | NSY-1 functions in the control of asymmetric expression of odor receptor gene str-2, odor discrimination, and odor chemotaxis, thus possibly in functional differentiation of the nervous system, the enzyme functions downstream of UNC-43 CaMKII | Caenorhabditis elegans | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.25 | apoptosis signal-regulating kinase 1 | - |
Mus musculus |
2.7.11.25 | apoptosis signal-regulating kinase 1 | - |
Homo sapiens |
2.7.11.25 | ASK1 | - |
Mus musculus |
2.7.11.25 | ASK1 | - |
Homo sapiens |
2.7.11.25 | MAPKKK | - |
Mus musculus |
2.7.11.25 | MAPKKK | - |
Homo sapiens |
2.7.11.25 | NSY-1 | - |
Caenorhabditis elegans |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.25 | ATP | - |
Mus musculus | |
2.7.11.25 | ATP | - |
Homo sapiens |