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Literature summary extracted from

  • Takeda, K.; Matsuzawa, A.; Nishitoh, H.; Ichijo, H.
    Roles of MAPKKK ASK1 in stress-induced cell death (2003), Cell Struct. Funct., 28, 23-29.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.25 additional information polymerization and phosphorylation activates the enzyme after dissociation of thioredoxin due to TNF-alpha treatment Mus musculus
2.7.11.25 additional information polymerization and phosphorylation activates the enzyme after dissociation of thioredoxin due to TNF-alpha treatment Homo sapiens
2.7.11.25 reactive oxygene species the enzyme is oxidative stress-induced Mus musculus
2.7.11.25 reactive oxygene species the enzyme is oxidative stress-induced Homo sapiens
2.7.11.25 TNF-alpha treatment with TNF-alpha dissociates the inhibitor thioredoxin from the enzyme's N-terminus Mus musculus
2.7.11.25 TNF-alpha treatment with TNF-alpha dissociates the inhibitor thioredoxin from the enzyme's N-terminus Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.25 thioredoxin the reduced form binds to the N-terminus Homo sapiens
2.7.11.25 thioredoxin the reduced form binds to the N-terminus Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.25 ATP + MKK3 Mus musculus activation of the p38 MAP kinase signaling pathway leading to apoptosis ADP + phosphorylated MKK3
-
?
2.7.11.25 ATP + MKK3 Homo sapiens activation of the p38 MAP kinase signaling pathway leading to apoptosis ADP + phosphorylated MKK3
-
?
2.7.11.25 ATP + MKK4 Mus musculus activation of the Jun N-terminal kinase, JNK, pathway leading to apoptosis ADP + phosphorylated MKK4
-
?
2.7.11.25 ATP + MKK4 Homo sapiens activation of the Jun N-terminal kinase, JNK, pathway leading to apoptosis ADP + phosphorylated MKK4
-
?
2.7.11.25 ATP + MKK6 Mus musculus activation of the p38 MAP kinase signaling pathway leading to apoptosis ADP + phosphorylated MKK6
-
?
2.7.11.25 ATP + MKK6 Homo sapiens activation of the p38 MAP kinase signaling pathway leading to apoptosis ADP + phosphorylated MKK6
-
?
2.7.11.25 ATP + MKK7 Mus musculus activation of the Jun N-terminal kinase, JNK, signaling pathway leading to apoptosis ADP + phosphorylated MKK7
-
?
2.7.11.25 ATP + MKK7 Homo sapiens activation of the Jun N-terminal kinase, JNK, signaling pathway leading to apoptosis ADP + phosphorylated MKK7
-
?
2.7.11.25 additional information Mus musculus activation mechanism of ASK1, overview, ASK1 is involved in oxidative stress-induced cell death and adaptation processes to various stresses, the enzyme is required for induction of apoptosis by e.g. Fas or TNF-alpha, or by the endoplasmic reticulum, mechanism ?
-
?
2.7.11.25 additional information Homo sapiens activation mechanism of ASK1, overview, ASK1 is involved in oxidative stress-induced cell death and adaptation processes to various stresses, the enzyme is required for induction of apoptosis by e.g. Fas or TNF-alpha, or by the endoplasmic reticulum, mechanism, ASK1 plays an important role in neuropathological alterations in polyQ diseases ?
-
?
2.7.11.25 additional information Caenorhabditis elegans NSY-1 functions in the control of asymmetric expression of odor receptor gene str-2, odor discrimination, and odor chemotaxis, thus possibly in functional differentiation of the nervous system, the enzyme functions downstream of UNC-43 CaMKII ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.25 Caenorhabditis elegans
-
-
-
2.7.11.25 Homo sapiens
-
-
-
2.7.11.25 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.25 phosphoprotein phosphorylation activates the enzyme Mus musculus
2.7.11.25 phosphoprotein phosphorylation activates the enzyme Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.11.25 ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate mechanism of ASK1 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.25 brain
-
Mus musculus
-
2.7.11.25 brain
-
Homo sapiens
-
2.7.11.25 neuron
-
Mus musculus
-
2.7.11.25 neuron
-
Homo sapiens
-
2.7.11.25 olfactory neuron
-
Caenorhabditis elegans
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.25 ATP + MKK3 a MAPKK Mus musculus ADP + phosphorylated MKK3
-
?
2.7.11.25 ATP + MKK3 a MAPKK Homo sapiens ADP + phosphorylated MKK3
-
?
2.7.11.25 ATP + MKK3 activation of the p38 MAP kinase signaling pathway leading to apoptosis Mus musculus ADP + phosphorylated MKK3
-
?
2.7.11.25 ATP + MKK3 activation of the p38 MAP kinase signaling pathway leading to apoptosis Homo sapiens ADP + phosphorylated MKK3
-
?
2.7.11.25 ATP + MKK4 activation of the Jun N-terminal kinase, JNK, pathway leading to apoptosis Mus musculus ADP + phosphorylated MKK4
-
?
2.7.11.25 ATP + MKK4 activation of the Jun N-terminal kinase, JNK, pathway leading to apoptosis Homo sapiens ADP + phosphorylated MKK4
-
?
2.7.11.25 ATP + MKK4 i.e. SEK1, a MAPKK Mus musculus ADP + phosphorylated MKK4
-
?
2.7.11.25 ATP + MKK4 i.e. SEK1, a MAPKK Homo sapiens ADP + phosphorylated MKK4
-
?
2.7.11.25 ATP + MKK6 a MAPKK Mus musculus ADP + phosphorylated MKK6
-
?
2.7.11.25 ATP + MKK6 a MAPKK Homo sapiens ADP + phosphorylated MKK6
-
?
2.7.11.25 ATP + MKK6 activation of the p38 MAP kinase signaling pathway leading to apoptosis Mus musculus ADP + phosphorylated MKK6
-
?
2.7.11.25 ATP + MKK6 activation of the p38 MAP kinase signaling pathway leading to apoptosis Homo sapiens ADP + phosphorylated MKK6
-
?
2.7.11.25 ATP + MKK7 a MAPKK Mus musculus ADP + phosphorylated MKK7
-
?
2.7.11.25 ATP + MKK7 a MAPKK Homo sapiens ADP + phosphorylated MKK7
-
?
2.7.11.25 ATP + MKK7 activation of the Jun N-terminal kinase, JNK, signaling pathway leading to apoptosis Mus musculus ADP + phosphorylated MKK7
-
?
2.7.11.25 ATP + MKK7 activation of the Jun N-terminal kinase, JNK, signaling pathway leading to apoptosis Homo sapiens ADP + phosphorylated MKK7
-
?
2.7.11.25 additional information activation mechanism of ASK1, overview, ASK1 is involved in oxidative stress-induced cell death and adaptation processes to various stresses, the enzyme is required for induction of apoptosis by e.g. Fas or TNF-alpha, or by the endoplasmic reticulum, mechanism Mus musculus ?
-
?
2.7.11.25 additional information activation mechanism of ASK1, overview, ASK1 is involved in oxidative stress-induced cell death and adaptation processes to various stresses, the enzyme is required for induction of apoptosis by e.g. Fas or TNF-alpha, or by the endoplasmic reticulum, mechanism, ASK1 plays an important role in neuropathological alterations in polyQ diseases Homo sapiens ?
-
?
2.7.11.25 additional information NSY-1 functions in the control of asymmetric expression of odor receptor gene str-2, odor discrimination, and odor chemotaxis, thus possibly in functional differentiation of the nervous system, the enzyme functions downstream of UNC-43 CaMKII Caenorhabditis elegans ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.25 apoptosis signal-regulating kinase 1
-
Mus musculus
2.7.11.25 apoptosis signal-regulating kinase 1
-
Homo sapiens
2.7.11.25 ASK1
-
Mus musculus
2.7.11.25 ASK1
-
Homo sapiens
2.7.11.25 MAPKKK
-
Mus musculus
2.7.11.25 MAPKKK
-
Homo sapiens
2.7.11.25 NSY-1
-
Caenorhabditis elegans

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.25 ATP
-
Mus musculus
2.7.11.25 ATP
-
Homo sapiens