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Literature summary extracted from

  • Hakamata, W.; Muroi, M.; Kadokura, K.; Nishio, T.; Oku, T.; Kimura, A.; Chiba, S.; Takatsuki, A.
    Aglycon specificity profiling of alpha-glucosidases using synthetic probes (2005), Bioorg. Med. Chem. Lett., 15, 1489-1492.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.20 2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol inhibition of isozymes HBGase I and HBGase II Apis mellifera
3.2.1.20 2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol
-
 Aspergillus niger
3.2.1.20 2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol
-
 Beta vulgaris
3.2.1.20 2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol mixed inhibition type Geobacillus stearothermophilus
3.2.1.20 2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol
-
 Oryza sativa
3.2.1.20 2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol competitive Saccharomyces cerevisiae
3.2.1.20 2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol
-
 Zea mays subsp. mays
3.2.1.20 2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol inhibition of isozymes HBGase I and HBGase II Apis mellifera
3.2.1.20 2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol
-
 Aspergillus niger
3.2.1.20 2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol
-
 Beta vulgaris
3.2.1.20 2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol
-
 Oryza sativa
3.2.1.20 2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol
-
 Zea mays subsp. mays
3.2.1.20 2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol inhibition of isozyme HBGase I Apis mellifera
3.2.1.20 2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Aspergillus niger
3.2.1.20 2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Beta vulgaris
3.2.1.20 2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Oryza sativa
3.2.1.20 2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Zea mays subsp. mays
3.2.1.20 2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol inhibition of isozymes HBGase I and HBGase II Apis mellifera
3.2.1.20 2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Aspergillus niger
3.2.1.20 2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Beta vulgaris
3.2.1.20 2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Oryza sativa
3.2.1.20 2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Rattus norvegicus
3.2.1.20 2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol competitive Saccharomyces cerevisiae
3.2.1.20 2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Zea mays subsp. mays
3.2.1.20 2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Aspergillus niger
3.2.1.20 2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Beta vulgaris
3.2.1.20 2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Oryza sativa
3.2.1.20 2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Saccharomyces cerevisiae
3.2.1.20 2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Zea mays subsp. mays
3.2.1.20 2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol inhibition of isozymes HBGase II and HBGase III Apis mellifera
3.2.1.20 2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Aspergillus niger
3.2.1.20 2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Beta vulgaris
3.2.1.20 2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Oryza sativa
3.2.1.20 2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Saccharomyces cerevisiae
3.2.1.20 2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Zea mays subsp. mays
3.2.1.20 2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol inhibition of isozyme HBGase II Apis mellifera
3.2.1.20 2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol
-
 Aspergillus niger
3.2.1.20 2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol
-
 Beta vulgaris
3.2.1.20 2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol
-
 Oryza sativa
3.2.1.20 2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol
-
 Zea mays subsp. mays
3.2.1.20 2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol inhibition of isozyme HBGase II Apis mellifera
3.2.1.20 2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol
-
 Beta vulgaris
3.2.1.20 2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol
-
 Oryza sativa
3.2.1.20 2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol
-
 Zea mays subsp. mays
3.2.1.20 castanospermine
-
 Apis mellifera
3.2.1.20 castanospermine
-
 Aspergillus niger
3.2.1.20 castanospermine
-
 Beta vulgaris
3.2.1.20 castanospermine
-
 Geobacillus stearothermophilus
3.2.1.20 castanospermine
-
 Oryza sativa
3.2.1.20 castanospermine
-
 Rattus norvegicus
3.2.1.20 castanospermine
-
 Saccharomyces cerevisiae
3.2.1.20 castanospermine
-
 Zea mays subsp. mays
3.2.1.20 conduritol B epoxide
-
 Apis mellifera
3.2.1.20 conduritol B epoxide
-
 Aspergillus niger
3.2.1.20 conduritol B epoxide
-
 Beta vulgaris
3.2.1.20 conduritol B epoxide
-
 Geobacillus stearothermophilus
3.2.1.20 conduritol B epoxide
-
 Oryza sativa
3.2.1.20 conduritol B epoxide
-
 Rattus norvegicus
3.2.1.20 conduritol B epoxide
-
 Saccharomyces cerevisiae
3.2.1.20 conduritol B epoxide
-
 Zea mays subsp. mays
3.2.1.20 D-gluconolactone
-
 Apis mellifera
3.2.1.20 D-gluconolactone
-
 Aspergillus niger
3.2.1.20 D-gluconolactone
-
 Beta vulgaris
3.2.1.20 D-gluconolactone
-
 Geobacillus stearothermophilus
3.2.1.20 D-gluconolactone
-
 Oryza sativa
3.2.1.20 D-gluconolactone
-
 Rattus norvegicus
3.2.1.20 D-gluconolactone
-
 Saccharomyces cerevisiae
3.2.1.20 D-gluconolactone
-
 Zea mays subsp. mays
3.2.1.20 deoxynojirimycin
-
 Apis mellifera
3.2.1.20 deoxynojirimycin
-
 Aspergillus niger
3.2.1.20 deoxynojirimycin
-
 Beta vulgaris
3.2.1.20 deoxynojirimycin
-
 Geobacillus stearothermophilus
3.2.1.20 deoxynojirimycin
-
 Oryza sativa
3.2.1.20 deoxynojirimycin
-
 Rattus norvegicus
3.2.1.20 deoxynojirimycin
-
 Saccharomyces cerevisiae
3.2.1.20 deoxynojirimycin
-
 Zea mays subsp. mays
3.2.1.20 additional information inhibition of isozymes, IC50 values, overview, no inhibition of all isozymes by 2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol Apis mellifera
3.2.1.20 additional information no inhibition by 2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol, IC50 values, overview Aspergillus niger
3.2.1.20 additional information IC50 values, overview Beta vulgaris
3.2.1.20 additional information no inhibition by 2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol, and 2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol, and 2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol, IC50 values, overview Geobacillus stearothermophilus
3.2.1.20 additional information IC50 values, overview Oryza sativa
3.2.1.20 additional information no inhibition by 2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol, 2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol, and 2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol, IC50 values of alpha-glucosidase I and alpha-glucosidase II, overview Rattus norvegicus
3.2.1.20 additional information no inhibition by 2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol, and 2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol, IC50 values, overview Saccharomyces cerevisiae
3.2.1.20 additional information IC50 values, overview Zea mays subsp. mays

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.20 endoplasmic reticulum the isozymes are endoplasmic reticulum processing alpha-glucosidases Rattus norvegicus 5783
-
3.2.1.20 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.20 Apis mellifera
-
 isozymes HBGase I-III
-
3.2.1.20 Aspergillus niger
-
-
-
3.2.1.20 Beta vulgaris
-
 sugar beet
-
3.2.1.20 Geobacillus stearothermophilus
-
-
-
3.2.1.20 Oryza sativa
-
-
-
3.2.1.20 Rattus norvegicus
-
-
-
3.2.1.20 Saccharomyces cerevisiae
-
-
-
3.2.1.20 Zea mays subsp. mays
-
 flint corn
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.20 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.20 additional information substrate aglycon specificity profiling, overview Beta vulgaris ?
-
 ?
3.2.1.20 additional information substrate aglycon specificity profiling, overview Rattus norvegicus ?
-
 ?
3.2.1.20 additional information substrate aglycon specificity profiling, overview Saccharomyces cerevisiae ?
-
 ?
3.2.1.20 additional information substrate aglycon specificity profiling, overview Geobacillus stearothermophilus ?
-
 ?
3.2.1.20 additional information substrate aglycon specificity profiling, overview Aspergillus niger ?
-
 ?
3.2.1.20 additional information substrate aglycon specificity profiling, overview Apis mellifera ?
-
 ?
3.2.1.20 additional information substrate aglycon specificity profiling, overview Oryza sativa ?
-
 ?
3.2.1.20 additional information substrate aglycon specificity profiling, overview Zea mays subsp. mays ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.20 alpha-glucosidase I
-
 Rattus norvegicus
3.2.1.20 alpha-glucosidase II
-
 Rattus norvegicus
3.2.1.20 HBGase I
-
 Apis mellifera
3.2.1.20 HBGase II
-
 Apis mellifera
3.2.1.20 HBGase III
-
 Apis mellifera
3.2.1.20 More the enzyme belongs to the alpha-glucosidase family 13 Saccharomyces cerevisiae
3.2.1.20 More the enzyme belongs to the alpha-glucosidase family 13 Geobacillus stearothermophilus
3.2.1.20 More the enzyme belongs to the alpha-glucosidase family 31 Beta vulgaris
3.2.1.20 More the enzyme belongs to the alpha-glucosidase family 31 Aspergillus niger
3.2.1.20 More the enzyme belongs to the alpha-glucosidase family 31 Oryza sativa
3.2.1.20 More the enzyme belongs to the alpha-glucosidase family 31 Zea mays subsp. mays

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.20 0.13
-
 2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol
-
 Saccharomyces cerevisiae
3.2.1.20 0.5
-
 2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Saccharomyces cerevisiae
3.2.1.20 0.58
-
 2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol
-
 Geobacillus stearothermophilus