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Literature summary extracted from
- Role of aminopeptidases in the blood pressure regulation (2004), Biol. Pharm. Bull., 27, 768-771.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.11.1 | genotyping | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.11.1 | K528R | A-LAP polymorphism, leads to hypertension | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.7 | amastatin | an APA inhibitor, enzyme inhibition leads to increased blood pressure | Rattus norvegicus |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.11.3 | membrane | membrane-bound placental enzyme is released into maternal blood flow via proteolytic cleavage by metalloproteases and metalloproteinases | Homo sapiens | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.1 | Zn2+ | A-LAP ia a zinc-metallopeptidase | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.1 | angiotensin II + H2O | Homo sapiens | i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe | Asp + angiotensin III | i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe | ? | |
| 3.4.11.1 | additional information | Homo sapiens | A-LAP plays a key role in the MHC class I antigen-presentation pathway, the enzyme is involved in the renin-angiotensin-system, RAS, and angiotensin II metabolism, and plays a role in blood pressure decrease through inactivation of angiotensin II, overview | ? | - |
? | |
| 3.4.11.3 | angiotensin III + H2O | Homo sapiens | the enzyme plays a role in blood pressure regulation via hydrolyzing vasopressin and angiotensin III | ? | - |
? | |
| 3.4.11.3 | Vasopressin + H2O | Homo sapiens | the enzyme plays a role in blood pressure regulation via hydrolyzing vasopressin and angiotensin III | ? | - |
? | |
| 3.4.11.7 | angiotensin II + H2O | Rattus norvegicus | angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure | Asp + angiotensin III | - |
? | |
| 3.4.11.7 | additional information | Rattus norvegicus | administration of purified enzyme into hypertensive rats leads to a decrease in blood pressure, while enzyme inhibition increases blood pressure | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.11.1 | Homo sapiens | - |
- |
- |
| 3.4.11.3 | Homo sapiens | - |
- |
- |
| 3.4.11.7 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.11.1 | adipocyte | - |
Homo sapiens | - |
| 3.4.11.1 | kidney | cortex | Homo sapiens | - |
| 3.4.11.3 | blood serum | during normal pregnancy, enzyme activity in maternal serum gradually increases to the maximum at near term | Homo sapiens | - |
| 3.4.11.3 | placenta | the enzyme is predominantly expressed in differentiated trophoblasts | Homo sapiens | - |
| 3.4.11.3 | trophoblast | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.1 | angiotensin II + H2O | i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe | Homo sapiens | Asp + angiotensin III | i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe | ? | |
| 3.4.11.1 | kallidin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.11.1 | additional information | A-LAP plays a key role in the MHC class I antigen-presentation pathway, the enzyme is involved in the renin-angiotensin-system, RAS, and angiotensin II metabolism, and plays a role in blood pressure decrease through inactivation of angiotensin II, overview | Homo sapiens | ? | - |
? | |
| 3.4.11.3 | angiotensin III + H2O | the enzyme plays a role in blood pressure regulation via hydrolyzing vasopressin and angiotensin III | Homo sapiens | ? | - |
? | |
| 3.4.11.3 | Vasopressin + H2O | the enzyme plays a role in blood pressure regulation via hydrolyzing vasopressin and angiotensin III | Homo sapiens | ? | - |
? | |
| 3.4.11.7 | angiotensin II + H2O | angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure | Rattus norvegicus | Asp + angiotensin III | - |
? | |
| 3.4.11.7 | angiotensin II + H2O | i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe | Rattus norvegicus | Asp + angiotensin III | i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe | ? | |
| 3.4.11.7 | additional information | administration of purified enzyme into hypertensive rats leads to a decrease in blood pressure, while enzyme inhibition increases blood pressure | Rattus norvegicus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.11.1 | A-LAP | - |
Homo sapiens |
| 3.4.11.1 | leucine aminopeptidase | - |
Homo sapiens |
| 3.4.11.1 | More | the enzyme belongs to the M1 peptidase family | Homo sapiens |
| 3.4.11.3 | P-LAP | - |
Homo sapiens |
| 3.4.11.3 | Placental leucine aminopeptidase | - |
Homo sapiens |
| 3.4.11.7 | aminopeptidase A | - |
Rattus norvegicus |
| 3.4.11.7 | APA | - |
Rattus norvegicus |
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