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Literature summary extracted from

  • Khersonsky, O.; Tawfik, D.S.
    Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase (2005), Biochemistry, 44, 6371-6382.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.2 1
-
4-chlorophenyl acetate
-
Homo sapiens
3.1.1.2 1.19
-
2,3-difluorophenyl acetate
-
Homo sapiens
3.1.1.2 1.2
-
phenyl acetate
-
Homo sapiens
3.1.1.2 1.26
-
p-tolyl acetate
-
Homo sapiens
3.1.1.2 1.4
-
3-fluorophenyl acetate
-
Homo sapiens
3.1.1.2 1.5
-
4-nitrophenyl acetate
-
Homo sapiens
3.1.1.2 1.5
-
2-fluorophenyl acetate
-
Homo sapiens
3.1.1.2 1.9
-
3-cyanophenyl acetate
-
Homo sapiens
3.1.1.2 2
-
4-acetoxy methyl benzoate
-
Homo sapiens
3.1.1.2 2
-
2,6-difluorophenyl acetate
-
Homo sapiens
3.1.1.2 2.1
-
3,4-dimethyl phenyl acetate
-
Homo sapiens
3.1.1.2 2.2
-
3-nitrophenyl acetate
-
Homo sapiens
3.1.1.2 2.23
-
2,4-difluorophenyl acetate
-
Homo sapiens
3.1.1.2 2.3
-
4-acetoxybenzaldehyde
-
Homo sapiens
3.1.1.2 2.6
-
4-acetoxyacetophenone
-
Homo sapiens
3.1.1.2 4.1
-
4-methoxy phenyl acetate
-
Homo sapiens
3.1.1.2 5
-
Benzyl acetate
-
Homo sapiens
3.1.1.2 5
-
1-phenylvinyl acetate
-
Homo sapiens
3.1.1.2 10
-
butyl acetate
-
Homo sapiens
3.1.1.2 13
-
propyl acetate
-
Homo sapiens
3.1.1.2 15.4
-
ethyl acetate
-
Homo sapiens
3.1.1.2 19
-
2,2,2-trifluoroethyl acetate
-
Homo sapiens
3.1.1.2 24.8
-
2,2-difluoroethyl acetate
-
Homo sapiens
3.1.1.2 54
-
2-fluoroethyl acetate
-
Homo sapiens
3.1.1.25 0.129
-
dihydrocoumarin pH 8.0 Homo sapiens
3.1.1.25 0.22
-
gamma-dodecanoic acid lactone pH 8.0 Homo sapiens
3.1.1.25 0.39
-
gamma-nonanoic acid lactone pH 8.0 Homo sapiens
3.1.1.25 0.57
-
delta-valerolactone pH 8.0 Homo sapiens
3.1.1.25 0.58
-
gamma-heptanolide pH 8.0 Homo sapiens
3.1.1.25 0.6
-
gamma-undecanoic acid lactone pH 8.0 Homo sapiens
3.1.1.25 0.812
-
delta-nonalactone pH 8.0 Homo sapiens
3.1.1.25 1
-
Gamma-caprolactone pH 8.0 Homo sapiens
3.1.1.25 4.3
-
pantoyl lactone pH 8.0 Homo sapiens
3.1.1.25 21
-
gamma-butyrolactone pH 8.0 Homo sapiens
3.1.8.1 0.8
-
4-nitrophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 0.91
-
2-fluoro 4-nitrophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 1.2
-
4-diethyl phosphate benzaldehyde pH 8.0 Homo sapiens
3.1.8.1 1.3
-
2,6-difluorophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 1.3
-
3-nitrophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 1.56
-
4-diethyl phosphate acetophenone pH 8.0 Homo sapiens
3.1.8.1 1.7
-
3-fluoro 4-nitrophenyl diethyl phosphate
-
Homo sapiens
3.1.8.1 1.8
-
3,5-dinitrophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 1.9
-
4-diethyl phosphate methyl benzoate pH 8.0 Homo sapiens
3.1.8.1 1.9
-
4-cyanophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 1.9
-
4-chlorophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 2
-
3-fluorophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 2.1
-
2,4-dinitrophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 2.1
-
3-cyanophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 4
-
pentafluorophenyl diethyl phosphate pH 8.0 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.2 Homo sapiens P27169
-
-
3.1.1.25 Homo sapiens P27169
-
-
3.1.8.1 Homo sapiens P27169
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.2 1-phenylvinyl acetate + H2O
-
Homo sapiens 1-phenylethylenol + acetate
-
?
3.1.1.2 2,2,2-trifluoroethyl acetate + H2O
-
Homo sapiens 2,2,2-trifluoroethanol + acetate
-
?
3.1.1.2 2,2-difluoroethyl acetate + H2O
-
Homo sapiens 2,2-difluoroethanol + acetate
-
?
3.1.1.2 2,3-difluorophenyl acetate + H2O
-
Homo sapiens 2,3-difluorophenol + acetate
-
?
3.1.1.2 2,4-difluorophenyl acetate + H2O
-
Homo sapiens 2,4-difluorophenol + acetate
-
?
3.1.1.2 2,6-difluorophenyl acetate + H2O
-
Homo sapiens 2,6-difluorophenol + acetate
-
?
3.1.1.2 2-fluoroethyl acetate + H2O
-
Homo sapiens 2-fluoroethanol + acetate
-
?
3.1.1.2 2-fluorophenyl acetate + H2O
-
Homo sapiens 2-fluorophenol + acetate
-
?
3.1.1.2 3,4-dimethyl phenyl acetate + H2O
-
Homo sapiens 3,4-dimethylphenol + acetate
-
?
3.1.1.2 3-cyanophenyl acetate + H2O
-
Homo sapiens 3-cyanophenol + acetate
-
?
3.1.1.2 3-fluorophenyl acetate + H2O
-
Homo sapiens 3-fluorophenol + acetate
-
?
3.1.1.2 3-nitrophenyl acetate + H2O
-
Homo sapiens 3-nitrophenol + acetate
-
?
3.1.1.2 4-acetoxyacetophenone + H2O
-
Homo sapiens 4-hydroxyacetophenone + acetate
-
?
3.1.1.2 4-acetoxybenzaldehyde + H2O
-
Homo sapiens 4-hydroxybenzaldehyde + acetate
-
?
3.1.1.2 4-chlorophenyl acetate + H2O
-
Homo sapiens 4-chlorophenol + acetate
-
?
3.1.1.2 4-cyanophenyl acetate + H2O
-
Homo sapiens 4-cyanophenol + acetate
-
?
3.1.1.2 4-diethyl phosphate methyl benzoate + H2O
-
Homo sapiens ?
-
?
3.1.1.2 4-methoxy phenyl acetate + H2O
-
Homo sapiens 4-methoxy phenol + acetate
-
?
3.1.1.2 4-methylphenyl acetate + H2O
-
Homo sapiens 4-methylphenol + acetate
-
?
3.1.1.2 4-nitrophenyl acetate + H2O
-
Homo sapiens 4-nitrophenol + acetate
-
?
3.1.1.2 benzyl acetate + H2O
-
Homo sapiens benzyl alcohol + acetate
-
?
3.1.1.2 butyl acetate + H2O
-
Homo sapiens butanol + acetate
-
?
3.1.1.2 ethyl acetate + H2O
-
Homo sapiens ethanol + acetate
-
?
3.1.1.2 isopropyl acetate + H2O
-
Homo sapiens isobutanol + acetate
-
?
3.1.1.2 methyl 4-(acetyloxy)benzoate + H2O
-
Homo sapiens methyl 4-hydroxybenzoate + acetate
-
?
3.1.1.2 phenyl acetate + H2O
-
Homo sapiens phenol + acetate
-
?
3.1.1.2 propyl acetate + H2O
-
Homo sapiens propanol + acetate
-
?
3.1.1.25 4-methoxyphenyl acetate + H2O
-
Homo sapiens 4-methoxyphenol + acetate
-
?
3.1.1.25 delta-nonalactone + H2O
-
Homo sapiens 5-hydroxynonanoic acid
-
?
3.1.1.25 delta-valerolactone + H2O
-
Homo sapiens 5-hydroxypentanoic acid
-
?
3.1.1.25 dihydrocoumarin + H2O
-
Homo sapiens 3-(2-hydroxyphenyl)propanoic acid
-
?
3.1.1.25 ethyl acetate + H2O
-
Homo sapiens ethanol + acetate
-
?
3.1.1.25 gamma-butyrolactone + H2O
-
Homo sapiens 4-hydroxybutanoic acid
-
?
3.1.1.25 gamma-caprolactone + H2O
-
Homo sapiens 4-hydroxyhexanoic acid
-
?
3.1.1.25 gamma-dodecanoic acid lactone + H2O
-
Homo sapiens 4-hydroxydodecanoic acid
-
?
3.1.1.25 gamma-heptanolide + H2O
-
Homo sapiens 4-hydroxyheptanoic acid
-
?
3.1.1.25 gamma-nonanoic acid lactone + H2O
-
Homo sapiens 4-hydroxynonanoic acid
-
?
3.1.1.25 gamma-undecanoic acid lactone + H2O
-
Homo sapiens 4-hydroxyundecanoic acid
-
?
3.1.1.25 pantoyl lactone + H2O
-
Homo sapiens 2,4-dihydroxy-3,3-dimethylbutanoic acid
-
?
3.1.8.1 2,4-dinitrophenyl diethyl phosphate + H2O
-
Homo sapiens 2,4-dinitrophenol + diethyl phosphate
-
?
3.1.8.1 2,6-difluorophenyl diethyl phosphate + H2O
-
Homo sapiens 2,6-difluorophenol + diethyl phosphate
-
?
3.1.8.1 2-fluoro-4-nitrophenyl diethyl phosphate + H2O
-
Homo sapiens 2-fluoro-4-nitrophenol + diethyl phosphate
-
?
3.1.8.1 3,5-dinitrophenyl diethyl phosphate + H2O
-
Homo sapiens 3,5-dinitrophenol + diethyl phosphate
-
?
3.1.8.1 3-cyanophenyl diethyl phosphate + H2O
-
Homo sapiens 3-cyanophenol + diethyl phosphate
-
?
3.1.8.1 3-fluoro-4-nitrophenyl diethyl phosphate + H2O
-
Homo sapiens 3-fluoro-4-nitrophenol + diethyl phosphate
-
?
3.1.8.1 3-fluorophenyl diethyl phosphate + H2O
-
Homo sapiens 3-fluorophenol + diethyl phosphate
-
?
3.1.8.1 3-nitrophenyl diethyl phosphate + H2O
-
Homo sapiens 3-nitrophenol + diethyl phosphate
-
?
3.1.8.1 4-acetoxy acetophenone + H2O
-
Homo sapiens ?
-
?
3.1.8.1 4-chlorophenyl diethyl phosphate + H2O
-
Homo sapiens 4-chlorophenol + diethyl phosphate
-
?
3.1.8.1 4-cyanophenyl diethyl phosphate + H2O
-
Homo sapiens 4-cyanophenol + diethyl phosphate
-
?
3.1.8.1 4-diethyl phosphate acetophenone + H2O
-
Homo sapiens 4-hydroxyacetophenone + diethyl phosphate
-
?
3.1.8.1 4-diethyl phosphate benzaldehyde + H2O
-
Homo sapiens 4-hydroxybenzaldehyde + diethyl phosphate
-
?
3.1.8.1 4-diethyl phosphate methyl benzoate + H2O
-
Homo sapiens methyl 4-hydroxybenzoate + diethyl phosphate
-
?
3.1.8.1 4-nitrophenyl diethyl phosphate + H2O
-
Homo sapiens 4-nitrophenol + diethyl phosphate
-
?
3.1.8.1 benzyl acetate + H2O
-
Homo sapiens ?
-
?
3.1.8.1 diethyl 4-chlorophenyl phosphate + H2O
-
Homo sapiens 4-chlorophenol + diethyl phosphate
-
?
3.1.8.1 ethyl acetate + H2O
-
Homo sapiens ?
-
?
3.1.8.1 pentafluorophenyl diethyl phosphate + H2O
-
Homo sapiens pentafluorophenol + diethyl phosphate
-
?
3.1.8.1 pentafluorophenyl diethyl phosphate + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.8.1 PON1
-
Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.1.2 0.0008
-
Benzyl acetate
-
Homo sapiens
3.1.1.2 0.02
-
Benzyl acetate pH 8.0 Homo sapiens
3.1.1.2 0.242
-
ethyl acetate
-
Homo sapiens
3.1.1.2 0.244
-
4-diethyl phosphate methyl benzoate pH 8.0 Homo sapiens
3.1.1.2 0.27
-
butyl acetate
-
Homo sapiens
3.1.1.2 0.4
-
propyl acetate
-
Homo sapiens
3.1.1.2 0.5
-
2-fluoroethyl acetate
-
Homo sapiens
3.1.1.2 0.82
-
2,2-difluoroethyl acetate
-
Homo sapiens
3.1.1.2 1
-
1-phenylvinyl acetate
-
Homo sapiens
3.1.1.2 4
-
2,2,2-trifluoroethyl acetate
-
Homo sapiens
3.1.1.2 13
-
4-acetoxyacetophenone pH 8.0 Homo sapiens
3.1.1.2 14
-
4-acetoxy methyl benzoate
-
Homo sapiens
3.1.1.2 23
-
4-cyanophenyl acetate
-
Homo sapiens
3.1.1.2 26
-
4-nitrophenyl acetate
-
Homo sapiens
3.1.1.2 26
-
4-acetoxybenzaldehyde
-
Homo sapiens
3.1.1.2 51
-
3,4-dimethyl phenyl acetate
-
Homo sapiens
3.1.1.2 59
-
3-nitrophenyl acetate
-
Homo sapiens
3.1.1.2 68
-
p-tolyl acetate
-
Homo sapiens
3.1.1.2 117
-
4-chlorophenyl acetate
-
Homo sapiens
3.1.1.2 125
-
3-cyanophenyl acetate
-
Homo sapiens
3.1.1.2 145
-
2,6-difluorophenyl acetate
-
Homo sapiens
3.1.1.2 334
-
2,4-difluorophenyl acetate
-
Homo sapiens
3.1.1.2 403
-
2,3-difluorophenyl acetate
-
Homo sapiens
3.1.1.2 431
-
2-fluorophenyl acetate
-
Homo sapiens
3.1.1.2 571
-
3-fluorophenyl acetate
-
Homo sapiens
3.1.1.2 698
-
phenyl acetate
-
Homo sapiens
3.1.1.25 11.9
-
pantoyl lactone pH 8.0 Homo sapiens
3.1.1.25 26.4
-
gamma-dodecanoic acid lactone pH 8.0 Homo sapiens
3.1.1.25 31
-
gamma-nonanoic acid lactone pH 8.0 Homo sapiens
3.1.1.25 34
-
gamma-heptanolide pH 8.0 Homo sapiens
3.1.1.25 39
-
4-methoxy phenyl acetate pH 8.0 Homo sapiens
3.1.1.25 44
-
Gamma-caprolactone pH 8.0 Homo sapiens
3.1.1.25 48
-
delta-nonalactone pH 8.0 Homo sapiens
3.1.1.25 62
-
gamma-undecanoic acid lactone pH 8.0 Homo sapiens
3.1.1.25 111
-
gamma-butyrolactone pH 8.0 Homo sapiens
3.1.1.25 152
-
dihydrocoumarin pH 8.0 Homo sapiens
3.1.1.25 210
-
delta-valerolactone pH 8.0 Homo sapiens
3.1.8.1 0.0008
-
4-chlorophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 0.0011
-
3-fluorophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 0.02
-
Benzyl acetate about, pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 0.062
-
2,6-difluorophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 0.076
-
3-nitrophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 0.178
-
3-cyanophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 0.24
-
ethyl acetate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 0.27
-
2,4-dinitrophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 0.4
-
4-cyanophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 0.44
-
4-diethyl phosphate acetophenone pH 8.0 Homo sapiens
3.1.8.1 0.47
-
4-diethyl phosphate benzaldehyde pH 8.0 Homo sapiens
3.1.8.1 0.6
-
pentafluorophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 3.7
-
2-fluoro 4-nitrophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 4.8
-
4-nitrophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 10.2
-
3,5-dinitrophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 13
-
4-acetoxy acetophenone pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 13.9
-
3-fluoro 4-nitrophenyl diethyl phosphate pH 8.0 Homo sapiens
3.1.8.1 656
-
3-fluorophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 678
-
pentafluorophenyl diethyl phosphate about, pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 840
-
3-nitrophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 848
-
4-chlorophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 950
-
2,6-difluorophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 1477
-
3,5-dinitrophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 1610
-
3-cyanophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 5485
-
4-diethyl phosphate methyl benzoate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 7495
-
4-cyanophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 8080
-
4-diethyl phosphate acetophenone pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 9160
-
2,4-dinitrophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 10520
-
4-nitrophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 11080
-
2-fluoro-4-nitrophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 11680
-
3-fluoro-4-nitrophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
3.1.8.1 12620
-
4-diethyl phosphate benzaldehyde pH 8.0, genetic variant PON1 G2E6 Homo sapiens