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Literature summary extracted from

  • Labesse, G.; Bucurenci, N.; Douguet, D.; Sakamoto, H.; Landais, S.; Gagyi, C.; Gilles, A.M.; Barzu, O.
    Comparative modelling and immunochemical reactivity of Escherichia coli UMP kinase (2002), Biochem. Biophys. Res. Commun., 294, 173-179.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.22
-
 Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
2.7.4.22 D168N as stable as wild-type Escherichia coli
2.7.4.22 D174N as stable as wild-type, impairs the function of the enzyme Escherichia coli
2.7.4.22 D201N impairs the function of the enzyme Escherichia coli
2.7.4.22 D77N affects enzyme activity and especially the allosteric regulation Escherichia coli
2.7.4.22 L226Q more insoluble than wild-type, impairs the stability of the enzyme Escherichia coli
2.7.4.22 P141L affects enzyme activity and especially the allosteric regulation Escherichia coli
2.7.4.22 P141Q more soluble than wild-type Escherichia coli
2.7.4.22 R62H as stable as wild-type, affects enzyme activity and especially the allosteric regulation Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.22 ATP + UMP Escherichia coli
-
 ADP + UDP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.22 Escherichia coli P0A7E9
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.4.22
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.22 ATP + UMP
-
 Escherichia coli ADP + UDP
-
 ?
2.7.4.22 ATP + UMP 30°C, pH 7.4, 2 mM MgCl2 Escherichia coli ADP + UDP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.22 UMP kinase
-
 Escherichia coli