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Literature summary extracted from

  • Banegas, I.; Prieto, I.; Alba, F.; Vives, F.; Araque, A.; Segarra, A.B.; Duran, R.; de Gasparo, M.; Ramirez, M.
    Angiotensinase activity is asymmetrically distributed in the amygdala, hippocampus and prefrontal cortex of the rat (2005), Behav. Brain Res., 156, 321-326.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.3 membrane bound to Rattus norvegicus 16020
-
3.4.11.7 membrane membrane-bound aspartyl aminopeptidase Rattus norvegicus 16020
-
3.4.11.21 soluble
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.3 additional information Rattus norvegicus the enzyme is involved in the metabolism of angiotensin ?
-
 ?
3.4.11.7 angiotensin II + H2O Rattus norvegicus aspartyl aminopeptidase and several other aminopeptidases, i.e. angiotensinases, are involved in angiotensin II and cholecystokinin, CCK, metabolism, angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure Asp + angiotensin III
-
 ?
3.4.11.21 angiotensin II + H2O Rattus norvegicus aspartyl aminopeptidase and several other aminopeptidases, i.e. angiotensinases, are involved in angiotensin II and cholecystokinin, CCK, metabolism, angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure Asp + angiotensin III
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.3 Rattus norvegicus
-
-
-
3.4.11.7 Rattus norvegicus
-
-
-
3.4.11.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.3 hippocampus cystinyl aminopeptidase is 300% higher in the left than in the right hippocampus Rattus norvegicus
-
3.4.11.3 prefrontal cortex cystinyl aminopeptidase is 100% higher in the left than in the right prefrontal cortex Rattus norvegicus
-
3.4.11.7 amygdala
-
 Rattus norvegicus
-
3.4.11.7 brain bilateral distribution of aminopeptidases in stress-related areas, overview Rattus norvegicus
-
3.4.11.7 brain cortex prefrontal Rattus norvegicus
-
3.4.11.7 hippocampus predominantly right hemisphere Rattus norvegicus
-
3.4.11.21 amygdala
-
 Rattus norvegicus
-
3.4.11.21 brain bilateral distribution of aminopeptidases in stress-related areas, overview Rattus norvegicus
-
3.4.11.21 hippocampus predominantly left hemisphere Rattus norvegicus
-
3.4.11.21 prefrontal cortex
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.3 additional information the enzyme is involved in the metabolism of angiotensin Rattus norvegicus ?
-
 ?
3.4.11.7 angiotensin II + H2O aspartyl aminopeptidase and several other aminopeptidases, i.e. angiotensinases, are involved in angiotensin II and cholecystokinin, CCK, metabolism, angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure Rattus norvegicus Asp + angiotensin III
-
 ?
3.4.11.7 angiotensin II + H2O i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus Asp + angiotensin III i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe ?
3.4.11.21 angiotensin II + H2O aspartyl aminopeptidase and several other aminopeptidases, i.e. angiotensinases, are involved in angiotensin II and cholecystokinin, CCK, metabolism, angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure Rattus norvegicus Asp + angiotensin III
-
 ?
3.4.11.21 angiotensin II + H2O i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus Asp + angiotensin III i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.3 CysAP
-
 Rattus norvegicus
3.4.11.7 angiotensinase
-
 Rattus norvegicus
3.4.11.7 GluAP
-
 Rattus norvegicus
3.4.11.7 glutamyl-AP
-
 Rattus norvegicus
3.4.11.7 membrane-bound aspartyl-AP
-
 Rattus norvegicus
3.4.11.21 angiotensinase
-
 Rattus norvegicus
3.4.11.21 AspAP
-
 Rattus norvegicus
3.4.11.21 aspartyl-AP
-
 Rattus norvegicus