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Literature summary extracted from

  • Dulon, S.; Leduc, D.; Cottrell, G.S.; D'Alayer, J.; Hansen, K.K.; Bunnett, N.W.; Hollenberg, M.D.; Pidard, D.; Chignard, M.
    Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells (2005), Am. J. Respir. Cell Mol. Biol., 32, 411-419.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.26 medicine enzyme can silence the function of proteinase-activated receptor-2 in the respiratory tract, thereby altering the host innate defense mechanisms and respiratory functions, and thus contributing to the setting of a disease like cystic fibrosis Pseudomonas aeruginosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.26 phosphoramidon N-(alpha-rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.26 PAR2 + H2O Pseudomonas aeruginosa
-
 ? i.e. proteinase-activated receptor 2, enzyme cleaves the N-terminal domain of PAR2 from the cell surface without triggering receptor endocytosis as trypsin does. Cleavage does not activate PAR2, but disarms the recptor for subsequent activation by trypsin ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.26 Pseudomonas aeruginosa
-
-
-
3.4.24.26 Pseudomonas aeruginosa P14756
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.26
-
 Pseudomonas aeruginosa

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.26 elastin-Congo red
-
 Pseudomonas aeruginosa ?
-
 ?
3.4.24.26 PAR2 + H2O
-
 Pseudomonas aeruginosa ? i.e. proteinase-activated receptor 2, enzyme cleaves the N-terminal domain of PAR2 from the cell surface without triggering receptor endocytosis as trypsin does. Cleavage does not activate PAR2, but disarms the recptor for subsequent activation by trypsin ?
3.4.24.26 proteinase-activated receptor 2 + H2O the enzyme cleaves proteinase-activated receptor 2 to remove the extracellular Flag epitope Pseudomonas aeruginosa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.26 elastolytic metalloproteinase
-
 Pseudomonas aeruginosa
3.4.24.26 EPa
-
 Pseudomonas aeruginosa
3.4.24.26 Pseudomonas aeruginosa elastase
-
 Pseudomonas aeruginosa