Literature summary extracted from

Hayaishi, O.
Utilization of superoxide anion by indoleamine oxygenase-catalyzed tryptophan and indoleamine oxidation (1996), Adv. Exp. Med. Biol., 398, 285-289.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.13.11.52	diethyldithiocarbamate	inhibits superoxide dismutase	Oryctolagus cuniculus
1.13.11.52	Inosine	0.1 mM, increases activity 5fold	Oryctolagus cuniculus
1.13.11.52	additional information	not induced by either tryptophan or glucocorticoid	Oryctolagus cuniculus
1.13.11.52	additional information	requires molecular oxygen and superoxide anion	Oryctolagus cuniculus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.13.11.52	Superoxide dismutase	can be inhibited by diethyldithiocarbamate	Oryctolagus cuniculus
1.13.11.52	tyron	-	Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.13.11.52	5-hydroxy-L-tryptophan + O2	Oryctolagus cuniculus	-	N-formyl-5-hydroxy-L-kynurenine	-	?
1.13.11.52	D-tryptophan + O2	Oryctolagus cuniculus	-	N-formyl-D-kynurenine	-	?
1.13.11.52	L-tryptophan + O2	Oryctolagus cuniculus	-	N-formyl-L-kynurenine	-	?
1.13.11.52	serotonin + O2	Oryctolagus cuniculus	-	?	-	?
1.13.11.52	tryptamine + O2	Oryctolagus cuniculus	-	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.13.11.52	Oryctolagus cuniculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.13.11.52	intestine	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.13.11.52	5-hydroxy-L-tryptophan + O2	-	Oryctolagus cuniculus	N-formyl-5-hydroxy-L-kynurenine	-	?
1.13.11.52	D-tryptophan + O2	-	Oryctolagus cuniculus	N-formyl-D-kynurenine	-	?
1.13.11.52	L-tryptophan + O2	-	Oryctolagus cuniculus	N-formyl-L-kynurenine	-	?
1.13.11.52	serotonin + O2	-	Oryctolagus cuniculus	?	-	?
1.13.11.52	tryptamine + O2	-	Oryctolagus cuniculus	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.13.11.52	IDO	-	Oryctolagus cuniculus

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Release 2023.1 (January 2023)