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Literature summary extracted from

  • Montaner, B.; Castillo-Avila, W.; Martinell, M.; Ollinger, R.; Aymami, J.; Giralt, E.; Perez-Tomas, R.
    DNA interaction and dual topoisomerase I and II inhibition properties of the anti-tumor drug prodigiosin (2005), Toxicol. Sci., 85, 870-879.
    View publication on PubMed

Application

EC Number Application Comment Organism
5.6.2.2 pharmacology the enzyme is a therapeutic target for the anti-tumor drug prodigiosin Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 prodigiosin red pigment of Serratia marcescens with apoptotic activity, anti-tumor drug, induces Cu2+-mediated pH-dependent DNA damage, inhibits the enzyme in vitro and in vivo by binding and intercalation with the DNA Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.2.2 KCl
-
 Homo sapiens
5.6.2.2 Mg2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.2.2 JURKAT cell
-
 Homo sapiens
-
5.6.2.2 MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 supercoiled pRYG DNA + ATP + H2O cleavage of supercoiled pRYG DNA Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 toposiomerase II
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.6.2.2 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6.2.2 8
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
5.6.2.2 ATP
-
 Homo sapiens