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Literature summary extracted from

  • Salgado, P.S.; Makeyev, E.V.; Butcher, S.J.; Bamford, D.H.; Stuart, D.I.; Grimes, J.M.
    The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase (2004), Structure, 12, 307-316.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.7.48 cocrystallization of RNA oligonucleotides with the polymerase Cystovirus phi6

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.48 Ca2+
-
 Cystovirus phi6

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.48 Mg2+ activation of the RNA/polymerase complex by the addition of substrate and Mg2+ initiates a single round of reaction within the crystal to form a dead-end complex that partially collapses within the enzyme active site Cystovirus phi6

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Cystovirus phi6 P11124
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn
-
 Cystovirus phi6 diphosphate + RNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 RNA-dependent RNA polymerase
-
 Cystovirus phi6