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Literature summary extracted from

  • Pessi, G.; Kociubinski, G.; Mamoun, C.B.
    A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation (2004), Proc. Natl. Acad. Sci. USA, 101, 6206-6211.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.103 via RNA isolated from different blood stages Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.103 miltefosine 50% inhibition at 0.05 mM, 90% inhibition at 0.1 mM Plasmodium falciparum
2.1.1.103 additional information not inhibitory: clofibric acid Plasmodium falciparum
2.1.1.103 phosphocholine product inhibition, 50% inhibition at 0.05 mM Plasmodium falciparum
2.1.1.103 S-adenosyl-L-homocysteine 50% inhibition at 0.05 mM Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.103 0.079
-
 Ethanolamine phosphate pH 8.6, 37°C Plasmodium falciparum
2.1.1.103 0.153
-
 S-adenosyl-L-methionine pH 8.6, 37°C Plasmodium falciparum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.103 31000
-
 x * 31000, calculated Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.103 additional information Plasmodium falciparum enzyme is involved in biosynthesis of phosphatidylcholine via phosphoethanolamine methylation. Model of pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.103 Plasmodium falciparum Q6T755 expression in Escherichia coli
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.103 additional information enzyme is involved in biosynthesis of phosphatidylcholine via phosphoethanolamine methylation. Model of pathway Plasmodium falciparum ?
-
 ?
2.1.1.103 S-adenosyl-L-methionine + ethanolamine phosphate
-
 Plasmodium falciparum S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.103 ? x * 31000, calculated Plasmodium falciparum
2.1.1.103 More monopartite enzyme with a single catalytic domain Plasmodium falciparum

Synonyms

EC Number Synonyms Comment Organism
2.1.1.103 Pfpmt
-
 Plasmodium falciparum

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.1.1.103 Plasmodium falciparum calculated
-
 5.42