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Literature summary extracted from

  • Mani, R.S.; Usova, E.V.; Eriksson, S.; Cass, C.E.
    Fluorescence studies of substrate binding to human recombinant deoxycytidine kinase (2004), Nucleosides Nucleotides Nucleic Acids, 23, 1343-1346.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.74 dCTP feedback inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.74 additional information
-
 additional information steady-state fluorescent measurements, substrate binding constants, recombinant enzyme Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.74 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.74 ATP + 2'-deoxyadenosine Homo sapiens
-
 ADP + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.74 ATP + 2'-deoxycytidine Homo sapiens
-
 ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 ATP + 2'-deoxyguanosine Homo sapiens
-
 ADP + 2'-deoxyguanosine 5'-phosphate
-
 ?
2.7.1.74 additional information Homo sapiens enzyme is active and medically important in anticancer and antiviral therapy due to high phosphorylation activity of prodrugs, overview ?
-
 ?
2.7.1.74 UTP + 2'-deoxyadenosine Homo sapiens
-
 UDP + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.74 UTP + 2'-deoxycytidine Homo sapiens preferred donor and acceptor substrates UDP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 UTP + 2'-deoxyguanosine Homo sapiens
-
 UDP + 2'-deoxyguanosine 5'-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + 2'-deoxyadenosine
-
 Homo sapiens ADP + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.74 ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 ATP + 2'-deoxyguanosine
-
 Homo sapiens ADP + 2'-deoxyguanosine 5'-phosphate
-
 ?
2.7.1.74 ATP + adenosine
-
 Homo sapiens ADP + adenosine 5'-phosphate
-
 ?
2.7.1.74 ATP + arabinosyl cytosine i.e. cytosar Homo sapiens ADP + arabinosyl cytosine 5'-phosphate
-
 ?
2.7.1.74 ATP + cladribine
-
 Homo sapiens ADP + cladribine 5'-phosphate
-
 ?
2.7.1.74 ATP + cytidine
-
 Homo sapiens ADP + cytidine 5'-phosphate
-
 ?
2.7.1.74 ATP + fludarabine
-
 Homo sapiens ADP + fludarabine 5'-phosphate
-
 ?
2.7.1.74 ATP + gemcitabine
-
 Homo sapiens ADP + gemcitabine 5'-phosphate
-
 ?
2.7.1.74 ATP + L-2',3'-dideoxy-3'-thiacytidine
-
 Homo sapiens ADP + L-2',3'-dideoxy-3'-thiacytidine 5'-phosphate
-
 ?
2.7.1.74 additional information enzyme is active and medically important in anticancer and antiviral therapy due to high phosphorylation activity of prodrugs, overview Homo sapiens ?
-
 ?
2.7.1.74 additional information broad substrate specificity, overview, binding of acceptor subtrates is more tightly in presence of phosphate donor molecules Homo sapiens ?
-
 ?
2.7.1.74 UTP + 2'-deoxyadenosine
-
 Homo sapiens UDP + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.74 UTP + 2'-deoxycytidine preferred donor and acceptor substrates Homo sapiens UDP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 UTP + 2'-deoxyguanosine
-
 Homo sapiens UDP + 2'-deoxyguanosine 5'-phosphate
-
 ?
2.7.1.74 UTP + adenosine
-
 Homo sapiens UDP + adenosine 5'-phosphate
-
 ?
2.7.1.74 UTP + arabinosyl cytosine i.e. cytosar Homo sapiens UDP + arabinosyl cytosine 5'-phosphate
-
 ?
2.7.1.74 UTP + cladribine
-
 Homo sapiens UDP + cladribine 5'-phosphate
-
 ?
2.7.1.74 UTP + cytidine
-
 Homo sapiens UDP + cytidine 5'-phosphate
-
 ?
2.7.1.74 UTP + fludarabine
-
 Homo sapiens UDP + fludarabine 5'-phosphate
-
 ?
2.7.1.74 UTP + gemcitabine
-
 Homo sapiens UDP + gemcitabine 5'-phosphate
-
 ?
2.7.1.74 UTP + L-2',3'-dideoxy-3'-thiacytidine
-
 Homo sapiens UDP + L-2',3'-dideoxy-3'-thiacytidine 5'-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.74 ATP
-
 Homo sapiens
2.7.1.74 UTP preferred phosphate donor Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.74 additional information
-
 additional information steady-state fluorescent measurement, inhibitor binding constant, recombinant enzyme Homo sapiens