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Literature summary extracted from

  • Pandalai, P.K.; Lyons, J.M.; Duffy, J.Y.; McLean, K.M.; Wagner, C.J.; Merrill, W.H.; Pearl, J.M.; Akhter, S.A.
    Role of the beta-adrenergic receptor kinase in myocardial dysfunction after brain death (2005), J. Thorac. Cardiovasc. Surg., 130, 1183-1189.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.15 sarcolemma
-
 Sus scrofa 42383
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.15 Mg2+
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor Sus scrofa betaARK is involved in myocardial beta-adrenergic receptor signaling, enzyme dysfunction can cause heart failure, regulation mechanism and physiology, overview ADP + phosphorylated beta-adrenergic receptor
-
 ?
2.7.11.15 additional information Sus scrofa brain death induction, as well as sham-operation of pigs, lead to uncoupling of the beta-adrenergic receptor with acutely increased myocardial beta-adrenergic receptor kinase activity leading to left ventricular dysfunction ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.15 heart
-
 Sus scrofa
-
2.7.11.15 myocardium
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor betaARK is involved in myocardial beta-adrenergic receptor signaling, enzyme dysfunction can cause heart failure, regulation mechanism and physiology, overview Sus scrofa ADP + phosphorylated beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor receptor desensitization by phosphorylation Sus scrofa ADP + phosphorylated beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + rhodopsin
-
 Sus scrofa ADP + phosphorylated rhodopsin
-
 ?
2.7.11.15 additional information brain death induction, as well as sham-operation of pigs, lead to uncoupling of the beta-adrenergic receptor with acutely increased myocardial beta-adrenergic receptor kinase activity leading to left ventricular dysfunction Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.15 betaARK
-
 Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.15 ATP
-
 Sus scrofa