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Literature summary extracted from

  • Werry, T.D.; Gregory, K.J.; Sexton, P.M.; Christopoulos, A.
    Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2 (2005), J. Neurochem., 93, 1603-1615.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.24 additional information ERK phosphorylation activates the enzyme activity, stimulation by 7TMD receptors, e.g. the serotonin 5-HT2c receptor Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.24 expression of ERK in CHO cells, co-expression of serotonin 5-HT2c receptor leads to increased ERK phosphorylation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 tyrphostin AG1478 EGFR-specific antagonist Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.24 ATP + a protein Homo sapiens
-
 ADP + a phosphoprotein
-
 ?
2.7.11.24 additional information Homo sapiens signaling pathway, including ERK, regulation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Homo sapiens
-
-
-
2.7.11.24 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.24 phosphoprotein ERKs are phosphorylated, involving protein kinase C and phospholipase D, in signaling pathways by kinases, which are stimulated by the serotonin 5-HT2c receptor, ERK phosphorylation activates its enzyme activity, overview Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.1 additional information serotonin 5-HT2c receptor signaling is largely independent from receptor tyrosine kinase activity Homo sapiens ?
-
 ?
2.7.11.24 ATP + a protein
-
 Homo sapiens ADP + a phosphoprotein
-
 ?
2.7.11.24 additional information signaling pathway, including ERK, regulation, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 Egfr
-
 Homo sapiens
2.7.10.1 EGFR tyrosine kinase
-
 Homo sapiens
2.7.10.1 receptor tyrosine kinase
-
 Homo sapiens
2.7.11.24 ERK1
-
 Homo sapiens
2.7.11.24 ERK2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.24 ATP
-
 Homo sapiens