Literature summary extracted from
Tellez-Valencia, A.; Olivares-Illana, V.; Hernandez-Santoyo, A.; Perez-Montfort, R.; Costas, M.; Rodriguez-Romero, A.; Lopez-Calahorra, F.; Tuena De Gomez-Puyou, M.; Gomez-Puyou, A.
Inactivation of triosephosphate isomerase from Trypanosoma cruzi by an agent that perturbs its dimer interface (2004), J. Mol. Biol., 341, 1355-1365.
Crystallization (Commentary)
EC Number |
Crystallization (Comment) |
Organism |
---|
5.3.1.1 |
hanging drop vapour diffusion method, crystals of the enzyme in complex with one molecule of 3-(2-benzothiazolylthio)-1-propanesulfonic acid diffract to a resolution of 2 A. Unit cell dimensions: a = 42.87, b = 75.57, c = 146.45 |
Trypanosoma cruzi |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
5.3.1.1 |
3-(2-benzothiazolylthio)-1-propanesulfonic acid |
binds to the dimer interface of the enzyme and thereby abolishes its function with a high level of selectivity |
Trypanosoma cruzi |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
5.3.1.1 |
Trypanosoma cruzi |
P52270 |
- |
- |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
5.3.1.1 |
TcTIM |
- |
Trypanosoma cruzi |