BRENDA - Enzyme Database show

Induction of prostacyclin/PGI(2) synthase expression after cerebral ischemia-reperfusion

Fang, Y.C.; Wu, J.S.; Chen, J.J.; Cheung, W.M.; Tseng, P.H.; Tam, K.B.; Shyue, S.K.; Lin, T.N.; J. Cereb. Blood Flow Metab. 26, 491-501 (2006)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
5.3.99.4
medicine
prostaglandin-I synthase protects the brain by enhancing prostaglandin I2 synthesis and creating a favorable prostaglandin I2/thromboxane A2 ratio, prostaglandin-I synthase expression after ischemic insult is important in promoting neuronal cell survival
Rattus norvegicus
Cloned(Commentary)
EC Number
Commentary
Organism
5.3.99.4
expression in HEK 293 cells
Rattus norvegicus
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.3.99.4
56000
-
monomer, SDS-PAGE, Western Blot
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Rattus norvegicus
-
Prostaglandin I2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.4
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
brain
ischemic cortex, ipsilateral penumbra area, pyriform cortex, hippocampus, leptomeninges
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
662509
Rattus norvegicus
Prostaglandin I2
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.4
medicine
prostaglandin-I synthase protects the brain by enhancing prostaglandin I2 synthesis and creating a favorable prostaglandin I2/thromboxane A2 ratio, prostaglandin-I synthase expression after ischemic insult is important in promoting neuronal cell survival
Rattus norvegicus
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.4
expression in HEK 293 cells
Rattus norvegicus
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.3.99.4
56000
-
monomer, SDS-PAGE, Western Blot
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Rattus norvegicus
-
Prostaglandin I2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
brain
ischemic cortex, ipsilateral penumbra area, pyriform cortex, hippocampus, leptomeninges
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
662509
Rattus norvegicus
Prostaglandin I2
-
-
-
?