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Literature summary extracted from

  • Fang, Y.C.; Wu, J.S.; Chen, J.J.; Cheung, W.M.; Tseng, P.H.; Tam, K.B.; Shyue, S.K.; Lin, T.N.
    Induction of prostacyclin/PGI(2) synthase expression after cerebral ischemia-reperfusion (2006), J. Cereb. Blood Flow Metab., 26, 491-501.
    View publication on PubMed

Application

EC Number Application Comment Organism
5.3.99.4 medicine prostaglandin-I synthase protects the brain by enhancing prostaglandin I2 synthesis and creating a favorable prostaglandin I2/thromboxane A2 ratio, prostaglandin-I synthase expression after ischemic insult is important in promoting neuronal cell survival Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.99.4 expression in HEK 293 cells Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.99.4 56000
-
 monomer, SDS-PAGE, Western Blot Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.4 Prostaglandin H2 Rattus norvegicus
-
 Prostaglandin I2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.4 brain ischemic cortex, ipsilateral penumbra area, pyriform cortex, hippocampus, leptomeninges Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 Prostaglandin H2
-
 Rattus norvegicus Prostaglandin I2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.4 PGIS
-
 Rattus norvegicus
5.3.99.4 prostacyclin synthase
-
 Rattus norvegicus
5.3.99.4 prostacyclin/PGI2 synthase
-
 Rattus norvegicus