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Literature summary extracted from

  • Tang, L.; Li, M.H.; Cao, P.; Wang, F.; Chang, W.R.; Bach, S.; Reinhardt, J.; Ferandin, Y.; Galons, H.; Wan, Y.; Gray, N.; Meijer, L.; Jiang, T.; Liang, D.C.
    Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives (2005), J. Biol. Chem., 280, 31220-31229.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.35 hanging drop vapor diffusion method, in complex with (R)-roscovitine and N6-methyl-(R)-roscovitine Ovis aries

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.35 (R)-roscovitine binds to the pyridoxal binding site Ovis aries

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.35 Zn2+ required Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.35 ATP + pyridoxal Ovis aries generates the active form of vitamin B6, which serves as cofactor for many enzymes ADP + pyridoxal 5'-phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.35 Ovis aries P82197
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.35
-
Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.35 brain
-
Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.35 ATP + pyridoxal
-
Ovis aries ADP + pyridoxal 5'-phosphate
-
?
2.7.1.35 ATP + pyridoxal generates the active form of vitamin B6, which serves as cofactor for many enzymes Ovis aries ADP + pyridoxal 5'-phosphate
-
?
2.7.1.35 ATP + pyridoxamine
-
Ovis aries ADP + pyridoxamine 5'-phosphate
-
?
2.7.1.35 ATP + pyridoxine
-
Ovis aries ADP + pyridoxine 5'-phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.35 PdxK
-
Ovis aries