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Literature summary extracted from

  • Lebreton, S.; Graciet, E.; Gontero, B.
    Modulation, via protein-protein interactions, of glyceraldehyde-3-phosphate dehydrogenase activity through redox phosphoribulokinase regulation (2003), J. Biol. Chem., 278, 12078-12084.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.19 dithiothreitol reduced form Chlamydomonas reinhardtii
2.7.1.19 thioredoxin reduced form, regulates activity via reversible reduction Chlamydomonas reinhardtii

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.19 cystine oxidized form, inhibition almost completely reversible by addition of reduced dithiothreitol Chlamydomonas reinhardtii
2.7.1.19 glutathione oxidized form, inhibition almost completely reversible by addition of reduced dithiothreitol Chlamydomonas reinhardtii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.19 ATP + D-ribulose 5-phosphate Chlamydomonas reinhardtii part of the Calvin cycle (reductive pentose phosphate pathway), involved in CO2 fixation in photosynthetic organisms ADP + D-ribulose 1,5-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.19 Chlamydomonas reinhardtii
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.19 glyceraldehyde-3-phosphate dehydrogenase/CP12/phosphoribulokinase complex Chlamydomonas reinhardtii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.19 ATP + D-ribulose 5-phosphate
-
 Chlamydomonas reinhardtii ADP + D-ribulose 1,5-bisphosphate
-
 ?
2.7.1.19 ATP + D-ribulose 5-phosphate part of the Calvin cycle (reductive pentose phosphate pathway), involved in CO2 fixation in photosynthetic organisms Chlamydomonas reinhardtii ADP + D-ribulose 1,5-bisphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.19 multimer glyceraldehyde-3-phosphate dehydrogenase/CP12/phosphoribulokinase complex, native form of enzyme Chlamydomonas reinhardtii

Synonyms

EC Number Synonyms Comment Organism
2.7.1.19 glyceraldehyde-3-phosphate dehydrogenase/CP12/phosphoribulokinase glyceraldehyde-3-phosphate dehydrogenase and phosphoribulokinase form a supramolecular complex with the regulatory peptide CP12, both enzyme activities strongly dependent on complex formation Chlamydomonas reinhardtii