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Literature summary extracted from

  • Jordan, S.W.; Cronan, J.E.
    A new metabolic link. The acyl carrier protein of lipid synthesis donates lipoic acid to the pyruvate dehydrogenase complex in Escherichia coli (1997), J. Biol. Chem., 272, 17903-17906.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.1.20 additional information not inhibitory: octanoyl-CoA Escherichia coli
6.3.1.20 additional information not inhibitory: octanoyl-CoA Neurospora crassa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.181 mitochondrion
-
 Neurospora crassa 5739
-
2.3.1.181 mitochondrion
-
 Pisum sativum 5739
-
2.8.1.8 mitochondrion
-
 Neurospora crassa 5739
-
2.8.1.8 mitochondrion
-
 Pisum sativum 5739
-
6.3.1.20 mitochondrion
-
 Neurospora crassa 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.181 octanoyl-[acyl-carrier protein] + protein Escherichia coli first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain) protein N6-(octanoyl)lysine + acyl-carrier protein
-
 ?
2.3.1.181 octanoyl-[acyl-carrier protein] + protein Neurospora crassa first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain) protein N6-(octanoyl)lysine + acyl-carrier protein
-
 ?
2.3.1.181 octanoyl-[acyl-carrier protein] + protein Pisum sativum first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain) protein N6-(octanoyl)lysine + acyl-carrier protein
-
 ?
2.8.1.8 additional information Escherichia coli final step in de novo biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain) ?
-
 ?
2.8.1.8 additional information Neurospora crassa final step in de novo biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain) ?
-
 ?
2.8.1.8 additional information Pisum sativum final step in de novo biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain) ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.181 Escherichia coli
-
-
-
2.3.1.181 Neurospora crassa
-
-
-
2.3.1.181 Pisum sativum
-
-
-
2.8.1.8 Escherichia coli
-
-
-
2.8.1.8 Neurospora crassa
-
-
-
2.8.1.8 Pisum sativum
-
-
-
6.3.1.20 Escherichia coli
-
-
-
6.3.1.20 Neurospora crassa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.181 octanoyl-[acyl-carrier protein] + protein
-
 Escherichia coli protein N6-(octanoyl)lysine + acyl-carrier protein
-
 ?
2.3.1.181 octanoyl-[acyl-carrier protein] + protein
-
 Neurospora crassa protein N6-(octanoyl)lysine + acyl-carrier protein
-
 ?
2.3.1.181 octanoyl-[acyl-carrier protein] + protein
-
 Pisum sativum protein N6-(octanoyl)lysine + acyl-carrier protein
-
 ?
2.3.1.181 octanoyl-[acyl-carrier protein] + protein first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain) Escherichia coli protein N6-(octanoyl)lysine + acyl-carrier protein
-
 ?
2.3.1.181 octanoyl-[acyl-carrier protein] + protein first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain) Neurospora crassa protein N6-(octanoyl)lysine + acyl-carrier protein
-
 ?
2.3.1.181 octanoyl-[acyl-carrier protein] + protein first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain) Pisum sativum protein N6-(octanoyl)lysine + acyl-carrier protein
-
 ?
2.8.1.8 additional information final step in de novo biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain) Escherichia coli ?
-
 ?
2.8.1.8 additional information final step in de novo biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain) Neurospora crassa ?
-
 ?
2.8.1.8 additional information final step in de novo biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain) Pisum sativum ?
-
 ?
6.3.1.20 octanoyl-ACP + lipoyl protein
-
 Escherichia coli octanoylated lipoyl protein + ACP
-
 ?
6.3.1.20 octanoyl-ACP + lipoyl protein
-
 Neurospora crassa octanoylated lipoyl protein + ACP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.181 LipB
-
 Escherichia coli
2.3.1.181 LipB
-
 Neurospora crassa
2.3.1.181 LipB
-
 Pisum sativum
2.3.1.181 lipoate/octanoate transferase
-
 Escherichia coli
2.3.1.181 lipoyl (octanoyl)-acyl carrier protein:protein transferase
-
 Escherichia coli
2.3.1.181 lipoyl(octanoyl)-[acyl-carrier-protein]-protein N-lipoyltransferase
-
 Escherichia coli
2.3.1.181 lipoyl(octanoyl)transferase
-
 Escherichia coli
2.3.1.181 lipoyltransferase
-
 Escherichia coli
2.3.1.181 octanoyl-[acyl carrier protein]-protein N-octanoyltransferase
-
 Escherichia coli