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Literature summary extracted from

  • Whitaker, R.J.; Gaines, C.G.; Jensen, R.A.
    A multispecific quintet of aromatic aminotransferases that overlap different biochemical pathways in Pseudomonas aeruginosa (1982), J. Biol. Chem., 257, 13550-13556.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.6.1.57 aromatic aminotransferase AT-1 is unstable to freeze-thaw treatment. With a single freeze-thaw cycle the enzyme loses about 50% of its original activity. Additional freeze-thaw treatments completely inactivate AT-1 Pseudomonas aeruginosa
2.6.1.57 aromatic aminotransferase AT-2 is stable to repeated freeze-thaw treatments Pseudomonas aeruginosa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.57 64000
-
 aromatic aminotransferase AT-1, gel filtration Pseudomonas aeruginosa
2.6.1.57 64000
-
 aromatic aminotransferase AT-2, gel filtration Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.57 additional information Pseudomonas aeruginosa role of enzyme AT-2 in L-Phe and L-Tyr biosynthesis ?
-
 ?
2.6.1.57 additional information Pseudomonas aeruginosa the enzyme AT-1 must primarily be engaged in L-aspartate and L-glutamate synthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.57 Pseudomonas aeruginosa
-
 aromatic aminotransferase AT-1
-
2.6.1.57 Pseudomonas aeruginosa
-
 aromatic aminotransferase AT-2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.57 2-oxoglutarate + Asp aromatic aminotransferase AT-1 Pseudomonas aeruginosa L-glutamate + 2-oxosuccinic acid
-
 ?
2.6.1.57 2-oxoglutarate + Asp aromatic aminotransferase AT-2 Pseudomonas aeruginosa L-glutamate + 2-oxosuccinic acid
-
 ?
2.6.1.57 2-oxoglutarate + Glu aromatic aminotransferase AT-1 Pseudomonas aeruginosa Glu + 2-oxoglutarate
-
 ?
2.6.1.57 2-oxoglutarate + Glu aromatic aminotransferase AT-2 Pseudomonas aeruginosa Glu + 2-oxoglutarate
-
 ?
2.6.1.57 2-oxoglutarate + L-Phe aromatic aminotransferase AT-1 Pseudomonas aeruginosa L-Glu + phenylpyruvate
-
 ?
2.6.1.57 2-oxoglutarate + L-Phe aromatic aminotransferase AT-2 Pseudomonas aeruginosa L-Glu + phenylpyruvate
-
 ?
2.6.1.57 2-oxoglutarate + Tyr aromatic aminotransferase AT-1 Pseudomonas aeruginosa L-glutamate + 4-hydroxyphenylpyruvate
-
 ?
2.6.1.57 2-oxoglutarate + Tyr aromatic aminotransferase AT-2 Pseudomonas aeruginosa L-glutamate + 4-hydroxyphenylpyruvate
-
 ?
2.6.1.57 4-hydroxyphenylpyruvate + Asp aromatic aminotransferase AT-1 Pseudomonas aeruginosa Tyr + 2-oxosuccinate
-
 ?
2.6.1.57 4-hydroxyphenylpyruvate + Asp aromatic aminotransferase AT-2 Pseudomonas aeruginosa Tyr + 2-oxosuccinate
-
 ?
2.6.1.57 4-hydroxyphenylpyruvate + Glu aromatic aminotransferase AT-1 Pseudomonas aeruginosa Tyr + 2-oxoglutarate
-
 ?
2.6.1.57 4-hydroxyphenylpyruvate + Glu aromatic aminotransferase AT-2 Pseudomonas aeruginosa Tyr + 2-oxoglutarate
-
 ?
2.6.1.57 4-hydroxyphenylpyruvate + Phe aromatic aminotransferase AT-1 Pseudomonas aeruginosa tyr + phenylpyruvate
-
 ?
2.6.1.57 4-hydroxyphenylpyruvate + Phe aromatic aminotransferase AT-2 Pseudomonas aeruginosa tyr + phenylpyruvate
-
 ?
2.6.1.57 4-hydroxyphenylpyruvate + Tyr aromatic aminotransferase AT-1 Pseudomonas aeruginosa Tyr + 4-hydroxyphenylpyruvate
-
 ?
2.6.1.57 4-hydroxyphenylpyruvate + Tyr aromatic aminotransferase AT-2 Pseudomonas aeruginosa Tyr + 4-hydroxyphenylpyruvate
-
 ?
2.6.1.57 additional information role of enzyme AT-2 in L-Phe and L-Tyr biosynthesis Pseudomonas aeruginosa ?
-
 ?
2.6.1.57 additional information the enzyme AT-1 must primarily be engaged in L-aspartate and L-glutamate synthesis Pseudomonas aeruginosa ?
-
 ?
2.6.1.57 oxaloacetate + Asp aromatic aminotransferase AT-1 Pseudomonas aeruginosa Asp + oxaloacetate
-
 ?
2.6.1.57 oxaloacetate + Asp aromatic aminotransferase AT-2 Pseudomonas aeruginosa Asp + oxaloacetate
-
 ?
2.6.1.57 oxaloacetate + Glu aromatic aminotransferase AT-1 Pseudomonas aeruginosa Asp + 2-oxoglutarate
-
 ?
2.6.1.57 oxaloacetate + Glu aromatic aminotransferase AT-2 Pseudomonas aeruginosa Asp + 2-oxoglutarate
-
 ?
2.6.1.57 oxaloacetate + Phe aromatic aminotransferase AT-1 Pseudomonas aeruginosa Asp + phenylpyruvate
-
 ?
2.6.1.57 oxaloacetate + Phe aromatic aminotransferase AT-2 Pseudomonas aeruginosa Asp + phenylpyruvate
-
 ?
2.6.1.57 oxaloacetate + Tyr aromatic aminotransferase AT-1 Pseudomonas aeruginosa Asp + 4-hydroxyphenylpyruvate
-
 ?
2.6.1.57 oxaloacetate + Tyr aromatic aminotransferase AT-2 Pseudomonas aeruginosa Asp + 4-hydroxyphenylpyruvate
-
 ?
2.6.1.57 phenylpyruvate + Asp aromatic aminotransferase AT-1 Pseudomonas aeruginosa Phe + 2-oxosuccinate
-
 ?
2.6.1.57 phenylpyruvate + Asp aromatic aminotransferase AT-2 Pseudomonas aeruginosa Phe + 2-oxosuccinate
-
 ?
2.6.1.57 phenylpyruvate + Glu aromatic aminotransferase AT-1 Pseudomonas aeruginosa Phe + 2-oxoglutarate
-
 ?
2.6.1.57 phenylpyruvate + Glu aromatic aminotransferase AT-2 Pseudomonas aeruginosa Phe + 2-oxoglutarate
-
 ?
2.6.1.57 phenylpyruvate + Phe aromatic aminotransferase AT-1 Pseudomonas aeruginosa Phe + phenylpyruvate
-
 ?
2.6.1.57 phenylpyruvate + Phe aromatic aminotransferase AT-2 Pseudomonas aeruginosa Phe + phenylpyruvate
-
 ?
2.6.1.57 phenylpyruvate + Tyr aromatic aminotransferase AT-1 Pseudomonas aeruginosa Phe + 3-(4-hydroxyphenyl)-2-oxopropanoic acid
-
 ?
2.6.1.57 phenylpyruvate + Tyr aromatic aminotransferase AT-2 Pseudomonas aeruginosa Phe + 3-(4-hydroxyphenyl)-2-oxopropanoic acid
-
 ?
2.6.1.57 prephenate + Asp aromatic aminotransferase AT-1 Pseudomonas aeruginosa arogenate + 2-oxosuccinate
-
 ?
2.6.1.57 prephenate + Asp aromatic aminotransferase AT-2 Pseudomonas aeruginosa arogenate + 2-oxosuccinate
-
 ?
2.6.1.57 prephenate + Glu aromatic aminotransferase AT-1 Pseudomonas aeruginosa arogenate + 2-oxoglutarate
-
 ?
2.6.1.57 prephenate + Glu aromatic aminotransferase AT-2 Pseudomonas aeruginosa arogenate + 2-oxoglutarate
-
 ?
2.6.1.57 prephenate + Phe aromatic aminotransferase AT-1 Pseudomonas aeruginosa arogenate + phenylpyruvate
-
 ?
2.6.1.57 prephenate + Phe aromatic aminotransferase AT-2 Pseudomonas aeruginosa arogenate + phenylpyruvate
-
 ?
2.6.1.57 prephenate + Tyr aromatic aminotransferase AT-1 Pseudomonas aeruginosa arogenate + 4-hydroxyphenylpyruvate
-
 ?
2.6.1.57 prephenate + Tyr aromatic aminotransferase AT-2 Pseudomonas aeruginosa arogenate + 4-hydroxyphenylpyruvate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.57 aromatic aminotransferase AT-1
-
 Pseudomonas aeruginosa
2.6.1.57 aromatic aminotransferase AT-2
-
 Pseudomonas aeruginosa
2.6.1.57 AT-1
-
 Pseudomonas aeruginosa
2.6.1.57 AT-2
-
 Pseudomonas aeruginosa

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.6.1.57 60
-
 inactivated at, aromatic aminotransferase AT-1 loses activity much more precipitously than does aromatic aminotransferase AT-2 Pseudomonas aeruginosa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.57 6.2
-
 L-glutamate, aromatic aminotransferase AT-1 Pseudomonas aeruginosa
2.6.1.57 7
-
 L-Phe, L-Tyr, L-Asp or L-Glu as substrate, aromatic aminotransferase AT-2 Pseudomonas aeruginosa
2.6.1.57 7.6
-
 L-Asp, aromatic aminotransferase AT-1 Pseudomonas aeruginosa
2.6.1.57 8.4
-
 L-Phe or L-Tyr, aromatic aminotransferase AT-1 Pseudomonas aeruginosa