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Literature summary extracted from
- Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis (2005), J. Biochem. Mol. Biol., 38, 633-638.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.3 | glutathione | - |
Mus musculus |  |
| 5.3.99.3 | additional information | IL-1 administration into the mouse cortex leads to elevated expression of cPGES and an increase in prostaglandin E2 | Mus musculus | |
| 5.3.99.3 | additional information | proinflammatory stimuli | Rattus norvegicus | |
| 5.3.99.3 | thiol reagents | - |
Homo sapiens | |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 5.3.99.3 | drug development | the enzyme represents a novel target for anti-inflammatory and anti-cancer drugs | Rattus norvegicus |
| 5.3.99.3 | medicine | a considerable increase of mPGES-2 expression is observed in human colorectal cancer | Homo sapiens |
| 5.3.99.3 | medicine | mPGES-1 is involved in various types of pathology including inflammation, pain hyperalgesia, fever, and cancer | Rattus norvegicus |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 5.3.99.3 | - |
Homo sapiens |
| 5.3.99.3 | - |
Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.3 | additional information | anti-inflammatory glucocorticoids | Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.3.99.3 | cytosol | - |
Mus musculus | 5829 | - |
| 5.3.99.3 | microsome | perinuclear | Rattus norvegicus | - |
- |
| 5.3.99.3 | microsome | Golgi membrane-associated | Homo sapiens | - |
- |
| 5.3.99.3 | additional information | cPGES is directly associated with and phosphorylated by casein kinase 2, cPGES, casein kinase 2 and Hsp90 form a stoichiometric complex of 1:1:1 immediately after cell activation, Hsp90 acts as an essential scaffold protein that brings cPGES and casein kinase 2 in proximity, thereby allowing their efficient functional interaction under physiological condition | Mus musculus | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.99.3 | Homo sapiens | - |
- |
- |
| 5.3.99.3 | Mus musculus | - |
- |
- |
| 5.3.99.3 | Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.3 | Prostaglandin H2 | - |
Mus musculus | Prostaglandin E2 | - |
? | |
| 5.3.99.3 | Prostaglandin H2 | - |
Homo sapiens | Prostaglandin E2 | - |
? | |
| 5.3.99.3 | Prostaglandin H2 | - |
Rattus norvegicus | Prostaglandin E2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.3.99.3 | dimer | crystal structure | Homo sapiens |
| 5.3.99.3 | trimer | crystal structure | Rattus norvegicus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.99.3 | CPGES | - |
Mus musculus |
| 5.3.99.3 | mPGES-1 | - |
Rattus norvegicus |
| 5.3.99.3 | mPGES-2 | - |
Homo sapiens |
| 5.3.99.3 | PGES | - |
Mus musculus |
| 5.3.99.3 | PGES | - |
Homo sapiens |
| 5.3.99.3 | PGES | - |
Rattus norvegicus |
| 5.3.99.3 | Prostaglandin E synthase | - |
Mus musculus |
| 5.3.99.3 | Prostaglandin E synthase | - |
Homo sapiens |
| 5.3.99.3 | Prostaglandin E synthase | - |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.3 | glutathione | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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