BRENDA - Enzyme Database show

Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis

Kudo, I.; Murakami, M.; J. Biochem. Mol. Biol. 38, 633-638 (2005)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
5.3.99.3
glutathione
-
Mus musculus
5.3.99.3
additional information
IL-1 administration into the mouse cortex leads to elevated expression of cPGES and an increase in prostaglandin E2
Mus musculus
5.3.99.3
additional information
proinflammatory stimuli
Rattus norvegicus
5.3.99.3
thiol reagents
-
Homo sapiens
Application
EC Number
Application
Commentary
Organism
5.3.99.3
drug development
the enzyme represents a novel target for anti-inflammatory and anti-cancer drugs
Rattus norvegicus
5.3.99.3
medicine
a considerable increase of mPGES-2 expression is observed in human colorectal cancer
Homo sapiens
5.3.99.3
medicine
mPGES-1 is involved in various types of pathology including inflammation, pain hyperalgesia, fever, and cancer
Rattus norvegicus
Crystallization (Commentary)
EC Number
Crystallization
Organism
5.3.99.3
-
Rattus norvegicus
5.3.99.3
-
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.3
additional information
anti-inflammatory glucocorticoids
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
cytosol
-
Mus musculus
5829
-
5.3.99.3
microsome
Golgi membrane-associated
Homo sapiens
-
-
5.3.99.3
microsome
perinuclear
Rattus norvegicus
-
-
5.3.99.3
additional information
cPGES is directly associated with and phosphorylated by casein kinase 2, cPGES, casein kinase 2 and Hsp90 form a stoichiometric complex of 1:1:1 immediately after cell activation, Hsp90 acts as an essential scaffold protein that brings cPGES and casein kinase 2 in proximity, thereby allowing their efficient functional interaction under physiological condition
Mus musculus
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.3
Homo sapiens
-
-
-
5.3.99.3
Mus musculus
-
-
-
5.3.99.3
Rattus norvegicus
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
662071
Mus musculus
Prostaglandin E2
-
-
-
?
5.3.99.3
Prostaglandin H2
-
662071
Homo sapiens
Prostaglandin E2
-
-
-
?
5.3.99.3
Prostaglandin H2
-
662071
Rattus norvegicus
Prostaglandin E2
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
5.3.99.3
dimer
crystal structure
Homo sapiens
5.3.99.3
trimer
crystal structure
Rattus norvegicus
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
5.3.99.3
glutathione
-
Rattus norvegicus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
5.3.99.3
glutathione
-
Mus musculus
5.3.99.3
additional information
IL-1 administration into the mouse cortex leads to elevated expression of cPGES and an increase in prostaglandin E2
Mus musculus
5.3.99.3
additional information
proinflammatory stimuli
Rattus norvegicus
5.3.99.3
thiol reagents
-
Homo sapiens
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.3
drug development
the enzyme represents a novel target for anti-inflammatory and anti-cancer drugs
Rattus norvegicus
5.3.99.3
medicine
a considerable increase of mPGES-2 expression is observed in human colorectal cancer
Homo sapiens
5.3.99.3
medicine
mPGES-1 is involved in various types of pathology including inflammation, pain hyperalgesia, fever, and cancer
Rattus norvegicus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
5.3.99.3
glutathione
-
Rattus norvegicus
Crystallization (Commentary) (protein specific)
EC Number
Crystallization
Organism
5.3.99.3
-
Homo sapiens
5.3.99.3
-
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.3
additional information
anti-inflammatory glucocorticoids
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
cytosol
-
Mus musculus
5829
-
5.3.99.3
microsome
Golgi membrane-associated
Homo sapiens
-
-
5.3.99.3
microsome
perinuclear
Rattus norvegicus
-
-
5.3.99.3
additional information
cPGES is directly associated with and phosphorylated by casein kinase 2, cPGES, casein kinase 2 and Hsp90 form a stoichiometric complex of 1:1:1 immediately after cell activation, Hsp90 acts as an essential scaffold protein that brings cPGES and casein kinase 2 in proximity, thereby allowing their efficient functional interaction under physiological condition
Mus musculus
-
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
662071
Mus musculus
Prostaglandin E2
-
-
-
?
5.3.99.3
Prostaglandin H2
-
662071
Homo sapiens
Prostaglandin E2
-
-
-
?
5.3.99.3
Prostaglandin H2
-
662071
Rattus norvegicus
Prostaglandin E2
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
5.3.99.3
dimer
crystal structure
Homo sapiens
5.3.99.3
trimer
crystal structure
Rattus norvegicus