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Literature summary extracted from
- Cupin-type phosphoglucose isomerases (Cupin-PGIs) constitute a novel metal-dependent PGI family representing a convergent line of PGI evolution (2005), J. Bacteriol., 187, 1621-1631.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.1.9 | 6-phosphogluconate | - |
Archaeoglobus fulgidus |  |
| 5.3.1.9 | 6-phosphogluconate | - |
Methanosarcina mazei | |
| 5.3.1.9 | 6-phosphogluconate | - |
Salmonella enterica | |
| 5.3.1.9 | EDTA | - |
Archaeoglobus fulgidus | |
| 5.3.1.9 | EDTA | - |
Methanosarcina mazei | |
| 5.3.1.9 | EDTA | - |
Salmonella enterica | |
| 5.3.1.9 | EDTA | - |
Sinorhizobium meliloti | |
| 5.3.1.9 | erythrose 4-phosphate | - |
Methanosarcina mazei | |
| 5.3.1.9 | erythrose 4-phosphate | - |
Sinorhizobium meliloti | |
| 5.3.1.9 | sorbitol-6-phosphate | - |
Archaeoglobus fulgidus | |
| 5.3.1.9 | sorbitol-6-phosphate | - |
Methanosarcina mazei | |
| 5.3.1.9 | sorbitol-6-phosphate | - |
Salmonella enterica | |
| 5.3.1.9 | sorbitol-6-phosphate | - |
Sinorhizobium meliloti | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.3.1.9 | 0.4 | - |
D-glucose 6-phosphate | pH 7.4, 50°C | Sinorhizobium meliloti | |
| 5.3.1.9 | 0.6 | - |
D-fructose 6-phosphate | pH 7.4, 50°C | Archaeoglobus fulgidus | |
| 5.3.1.9 | 0.6 | - |
D-glucose 6-phosphate | pH 7.4, 50°C | Archaeoglobus fulgidus | |
| 5.3.1.9 | 0.7 | - |
D-fructose 6-phosphate | pH 7.6, 37°C | Methanosarcina mazei | |
| 5.3.1.9 | 0.8 | - |
D-fructose 6-phosphate | pH 7.4, 50°C | Sinorhizobium meliloti | |
| 5.3.1.9 | 1 | - |
D-glucose 6-phosphate | pH 7.6, 37°C | Methanosarcina mazei | |
| 5.3.1.9 | 1 | - |
D-glucose 6-phosphate | pH 7.2, 37°C | Salmonella enterica | |
| 5.3.1.9 | 3 | - |
D-fructose 6-phosphate | pH 7.2, 37°C | Salmonella enterica | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.3.1.9 | 26834 | - |
2 * 26834, calculated, 2 * 32000, SDS-PAGE | Salmonella enterica |
| 5.3.1.9 | 27000 | - |
analytical ultracentrifugation | Archaeoglobus fulgidus |
| 5.3.1.9 | 27000 | - |
2 * 34684, calculated, 2 * 27000, SDS-PAGE | Sinorhizobium meliloti |
| 5.3.1.9 | 27424 | - |
1 * 27424, calculated, 1 * 28000, SDS-PAGE | Archaeoglobus fulgidus |
| 5.3.1.9 | 28000 | - |
gel filtration | Archaeoglobus fulgidus |
| 5.3.1.9 | 28000 | - |
gel filtration | Methanosarcina mazei |
| 5.3.1.9 | 30209 | - |
1 * 30209, calculated, 1 * 28000, SDS-PAGE | Methanosarcina mazei |
| 5.3.1.9 | 32000 | - |
2 * 26834, calculated, 2 * 32000, SDS-PAGE | Salmonella enterica |
| 5.3.1.9 | 34684 | - |
2 * 34684, calculated, 2 * 27000, SDS-PAGE | Sinorhizobium meliloti |
| 5.3.1.9 | 43000 | - |
gel filtration | Sinorhizobium meliloti |
| 5.3.1.9 | 67000 | - |
gel filtration | Salmonella enterica |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.1.9 | Archaeoglobus fulgidus | - |
- |
- |
| 5.3.1.9 | Methanosarcina mazei | - |
- |
- |
| 5.3.1.9 | Salmonella enterica | - |
serovar typhimurium | - |
| 5.3.1.9 | Sinorhizobium meliloti | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.1.9 | D-fructose 6-phosphate | - |
Sinorhizobium meliloti | D-glucose 6-phosphate | - |
r | |
| 5.3.1.9 | D-fructose 6-phosphate | - |
Salmonella enterica | D-glucose 6-phosphate | - |
r | |
| 5.3.1.9 | D-fructose 6-phosphate | - |
Archaeoglobus fulgidus | D-glucose 6-phosphate | - |
r | |
| 5.3.1.9 | D-fructose 6-phosphate | - |
Methanosarcina mazei | D-glucose 6-phosphate | - |
r | |
| 5.3.1.9 | D-glucose 6-phosphate | - |
Sinorhizobium meliloti | D-fructose 6-phosphate | - |
r | |
| 5.3.1.9 | D-glucose 6-phosphate | - |
Salmonella enterica | D-fructose 6-phosphate | - |
r | |
| 5.3.1.9 | D-glucose 6-phosphate | - |
Archaeoglobus fulgidus | D-fructose 6-phosphate | - |
r | |
| 5.3.1.9 | D-glucose 6-phosphate | - |
Methanosarcina mazei | D-fructose 6-phosphate | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.3.1.9 | dimer | 2 * 26834, calculated, 2 * 32000, SDS-PAGE | Salmonella enterica |
| 5.3.1.9 | dimer | 2 * 34684, calculated, 2 * 27000, SDS-PAGE | Sinorhizobium meliloti |
| 5.3.1.9 | monomer | 1 * 27424, calculated, 1 * 28000, SDS-PAGE | Archaeoglobus fulgidus |
| 5.3.1.9 | monomer | 1 * 30209, calculated, 1 * 28000, SDS-PAGE | Methanosarcina mazei |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.1.9 | Cupin-PGI | - |
Sinorhizobium meliloti |
| 5.3.1.9 | Cupin-PGI | - |
Salmonella enterica |
| 5.3.1.9 | Cupin-PGI | - |
Archaeoglobus fulgidus |
| 5.3.1.9 | Cupin-PGI | - |
Methanosarcina mazei |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 5.3.1.9 | 55 | - |
- |
Salmonella enterica |
| 5.3.1.9 | 57 | - |
- |
Sinorhizobium meliloti |
| 5.3.1.9 | 57 | - |
- |
Methanosarcina mazei |
| 5.3.1.9 | 82 | - |
- |
Archaeoglobus fulgidus |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 5.3.1.9 | 58 | - |
melting temperature | Sinorhizobium meliloti |
| 5.3.1.9 | 64 | - |
melting temperature | Salmonella enterica |
| 5.3.1.9 | 97 | - |
melting temperature | Archaeoglobus fulgidus |
| 5.3.1.9 | 97 | - |
melting temperature | Methanosarcina mazei |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 5.3.1.9 | 7.2 | - |
- |
Salmonella enterica |
| 5.3.1.9 | 7.4 | - |
- |
Sinorhizobium meliloti |
| 5.3.1.9 | 7.4 | - |
- |
Archaeoglobus fulgidus |
| 5.3.1.9 | 7.6 | - |
- |
Methanosarcina mazei |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.3.1.9 | 0.03 | - |
sorbitol-6-phosphate | pH 7.6, 37°C | Methanosarcina mazei | |
| 5.3.1.9 | 0.15 | - |
6-phosphogluconate | pH 7.6, 37°C | Methanosarcina mazei | |
| 5.3.1.9 | 0.36 | - |
sorbitol-6-phosphate | pH 7.2, 37°C | Salmonella enterica | |
| 5.3.1.9 | 0.54 | - |
sorbitol-6-phosphate | pH 7.4, 50°C | Sinorhizobium meliloti | |
| 5.3.1.9 | 0.67 | - |
6-phosphogluconate | pH 7.4, 50°C | Archaeoglobus fulgidus | |
| 5.3.1.9 | 0.7 | - |
sorbitol-6-phosphate | pH 7.4, 50°C | Archaeoglobus fulgidus | |
| 5.3.1.9 | 1.8 | - |
erythrose 4-phosphate | pH 7.4, 50°C | Sinorhizobium meliloti | |
| 5.3.1.9 | 1.8 | - |
erythrose 4-phosphate | pH 7.4, 50°C | Methanosarcina mazei | |
| 5.3.1.9 | 2 | 10 | EDTA | pH 7.4, 50°C | Sinorhizobium meliloti | |
| 5.3.1.9 | 3 | - |
6-phosphogluconate | pH 7.2, 37°C | Salmonella enterica | |
| 5.3.1.9 | 97 | - |
EDTA | pH 7.4, 50°C | Archaeoglobus fulgidus | |
| 5.3.1.9 | 101 | - |
EDTA | pH 7.6, 37°C | Methanosarcina mazei | |
| 5.3.1.9 | 120 | - |
EDTA | pH 7.2, 37°C | Salmonella enterica | |
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