Literature summary extracted from
Tremblay, L.W.; Zhang, G.; Dai, J.; Dunaway-Mariano, D.; Allen, K.N.
Chemical confirmation of a pentavalent phosphorane in complex with beta-phosphoglucomutase (2005), J. Am. Chem. Soc., 127, 5298-5299.
Crystallization (Commentary)
EC Number |
Crystallization (Comment) |
Organism |
---|
5.4.2.6 |
both in complex with inhibitor alpha-D-galactose 1-phosphate or substrate beta-D-glucose 1-phosphate |
Lactococcus lactis |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
5.4.2.6 |
alpha-D-galactose 1-phosphate |
competitive |
Lactococcus lactis |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
5.4.2.6 |
Lactococcus lactis |
P71447 |
- |
- |
Reaction
EC Number |
Reaction |
Comment |
Organism |
Reaction ID |
---|
5.4.2.6 |
beta-D-Glucose 1-phosphate = beta-D-glucose 6-phosphate |
mechanism is a nucleophilic substitution via an associative pathway, enzyme stablizes the phosphorane intermediate along that pathway |
Lactococcus lactis |
|
Ki Value [mM]
EC Number |
Ki Value [mM] |
Ki Value maximum [mM] |
Inhibitor |
Comment |
Organism |
Structure |
---|
5.4.2.6 |
0.03 |
- |
alpha-D-galactose 1-phosphate |
- |
Lactococcus lactis |
|