Literature summary extracted from
Schiott, B.; Bruice, T.C.
Reaction mechanism of soluble epoxide hydrolase: insights from molecular dynamics simulations (2002), J. Am. Chem. Soc., 124, 14558-14570.
Crystallization (Commentary)
EC Number |
Crystallization (Comment) |
Organism |
---|
3.3.2.10 |
analysis of several crystal structures of apoenzyme and enzyme bound to inhibitor urea for molecular dynamics simulations and determination of active site conformation replacing the inhibitor by substrate trans-methylstyrene oxide in the crystal structure model, minimized structure models |
Mus musculus |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
3.3.2.10 |
Urea |
- |
Mus musculus |
|
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
---|
3.3.2.10 |
cytosol |
- |
Mus musculus |
5829 |
- |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.3.2.10 |
Mus musculus |
P34914 |
- |
- |
Reaction
EC Number |
Reaction |
Comment |
Organism |
Reaction ID |
---|
3.3.2.10 |
an epoxide + H2O = a glycol |
detailed reaction mechanism, molecular dynamics simulations, detailed analysis of substrate binding to the active site and determination of the preferred conformation, involving Tyr381, Tyr465, and His523 |
Mus musculus |
|
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
3.3.2.10 |
(1S,2S)-trans-methylstyrene oxide + H2O |
a hydrogen bond from Tyr465 to the substrate oxygen is essential for controlling the regioselectivity of the reaction |
Mus musculus |
? |
- |
r |
|
Subunits
EC Number |
Subunits |
Comment |
Organism |
---|
3.3.2.10 |
More |
structure determination and analysis |
Mus musculus |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
3.3.2.10 |
SEH |
- |
Mus musculus |