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Literature summary extracted from

  • Jo, J.Y.; Gonzalez de Mejia, E.; Lila, M.A.
    Effects of grape cell culture extracts on human topoisomerase II catalytic activity and characterization of active fractions (2005), J. Agric. Food Chem., 53, 2489-2498.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 additional information inhibitory effect of grape, a Vitis sp. hybrid, cell culture extract fractions on enzyme activity, the fractions contain flavonoids and stilbenes which might be responsible for the inhibition, extract analysis reveals several compounds, overview Homo sapiens
5.6.2.2 quercetin
-
 Homo sapiens
5.6.2.2 resveratrol
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.2.2 KCl
-
 Homo sapiens
5.6.2.2 Mg2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 supercoiled pRYG DNA + ATP + H2O relaxation and cleavage of supercoiled pRYG DNA Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 Topoisomerase II
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.6.2.2 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6.2.2 8
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
5.6.2.2 ATP
-
 Homo sapiens