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Literature summary extracted from

  • Choi, H.P.; Hong, J.W.; Rhee, K.H.; Sung, H.C.
    Cloning, expression, and characterization of 5-aminolevulinic acid synthase from Rhodopseudomonas palustris KUGB306 (2004), FEMS Microbiol. Lett., 236, 175-181.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.37
-
 Rhodopseudomonas palustris

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.37 Co2+ 1 mM, strong Rhodopseudomonas palustris
2.3.1.37 Cu2+ 1 mM, complete inhibition Rhodopseudomonas palustris
2.3.1.37 Fe2+ 1 mM, strong Rhodopseudomonas palustris
2.3.1.37 K+ slight inhibition Rhodopseudomonas palustris
2.3.1.37 Mg2+ slight inhibition Rhodopseudomonas palustris
2.3.1.37 Pb2+ 1 mM, strong Rhodopseudomonas palustris
2.3.1.37 Zn2+ 1 mM, complete inhibition Rhodopseudomonas palustris

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.37 2.01
-
 glycine pH 7.5 Rhodopseudomonas palustris
2.3.1.37 49.55
-
 succinyl-CoA pH 7.5 Rhodopseudomonas palustris

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Rhodopseudomonas palustris Q6RVB3
-
-
2.3.1.37 Rhodopseudomonas palustris KUGB306 Q6RVB3
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.37 succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 mechanism, aldimine linkage between pyridoxal 5’-phosphate and enzyme Rhodopseudomonas palustris
a

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.37 27.73
-
 pH 7.5 Rhodopseudomonas palustris

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
 Rhodopseudomonas palustris 5-aminolevulinate + CoA + CO2
-
 ?
2.3.1.37 succinyl-CoA + glycine
-
 Rhodopseudomonas palustris KUGB306 5-aminolevulinate + CoA + CO2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.37 35 40
-
 Rhodopseudomonas palustris

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.3.1.37 50
-
 retains about 80% of activity Rhodopseudomonas palustris

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.37 7.5 8
-
 Rhodopseudomonas palustris

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.3.1.37 9
-
 retains about 80% of activity Rhodopseudomonas palustris

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
 Rhodopseudomonas palustris