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Literature summary extracted from

  • Dietze, E.C.; Stephens, J.; Magdalou, J.; Bender, D.M.; Moyer, M.; Fowler, B.; Hammock, B.D.
    Inhibition of human and murine cytosolic epoxide hydrolase by group-selective reagents (1993), Comp. Biochem. Physiol. B, 104, 299-308.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.10 2,2'-Dithiopyridine 73% inhibition at 1 mM at pH 7.4 Homo sapiens
3.3.2.10 2,2'-Dithiopyridine 66% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 2-Bromo-4'-nitroacetophenone complete inhibition at 1 mM at pH 7.4 Homo sapiens
3.3.2.10 2-Bromo-4'-nitroacetophenone 81% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 4-nitrobenzenesulfonyl fluoride 94% inhibition at 1 mM at pH 7.4 Homo sapiens
3.3.2.10 4-nitrobenzenesulfonyl fluoride 47% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 acetaldehyde/borohydride 13% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 benzaldehyde/borohydride 16% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 benzyl phenylmetanethiosulfonate complete inhibition at 1 mM at pH 7.4 Homo sapiens
3.3.2.10 benzyl phenylmethanethiosulfonate 94% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 carbodiimide/glycine methyl ester 48% inhibition at 1 mM at pH 5.2, no inhibition at pH 7.4 Homo sapiens
3.3.2.10 carbodiimide/glycine methyl ester 65% inhibition at 1 mM at pH 5.2, 17% at pH 7.4 Mus musculus
3.3.2.10 diethyldicarbonate 72% inhibition at 1 mM at pH 7.4 Homo sapiens
3.3.2.10 diethyldicarbonate 80% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 diisopropyl fluorophosphate 16% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 DTNB 86% inhibition at 1 mM at pH 7.4 Homo sapiens
3.3.2.10 DTNB 59% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 methyl methanethiosulfonate 89% inhibition at 1 mM at pH 7.4 Homo sapiens
3.3.2.10 methyl methanethiosulfonate 89% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 additional information N-acetyl imidazole, N-bromosuccimide, cyclohexandione, acetaldehyde/borohydride and benzaldehyde/borohydride are poor inhibitors, no inhibition by PMSF and diisopropyl fluorophosphate, no inhibition by amino-, guanido-, or activated serine-selective reagents Homo sapiens
3.3.2.10 additional information cyclohexandione is a poor inhibitor, no inhibition by amino-, guanido-, or activated serine-selective reagents Mus musculus
3.3.2.10 N-acetyl imidazole 12% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 N-bromosuccimide 98% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 N-ethylmaleimide 98% inhibition at 1 mM at pH 7.4 Homo sapiens
3.3.2.10 N-ethylmaleimide 21% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 N-Phenylmaleimide 97% inhibition at 1 mM at pH 7.4 Homo sapiens
3.3.2.10 N-Phenylmaleimide 60% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 ninhydrin 13% inhibition at 1 mM at pH 7.4 Homo sapiens
3.3.2.10 ninhydrin 12% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 Phenylglyoxal 19% inhibition at 1 mM at pH 7.4 Homo sapiens
3.3.2.10 Phenylglyoxal 22% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 phenylthioisocyanate 54% inhibition at 1 mM at pH 7.4 Homo sapiens
3.3.2.10 phenylthioisocyanate 34% inhibition at 1 mM at pH 7.4 Mus musculus
3.3.2.10 PMSF 27% inhibition at 1 mM at pH 7.4 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.10 cytosol
-
 Mus musculus 5829
-
3.3.2.10 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.10 Homo sapiens
-
-
-
3.3.2.10 Mus musculus
-
 Swiss Webster mice
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.3.2.10 from liver by affinity chromatography Mus musculus
3.3.2.10 from liver by affinity chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.10 liver
-
 Mus musculus
-
3.3.2.10 liver
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.3.2.10 CEH
-
 Mus musculus
3.3.2.10 CEH
-
 Homo sapiens
3.3.2.10 Cytosolic epoxide hydrolase
-
 Mus musculus
3.3.2.10 Cytosolic epoxide hydrolase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.3.2.10 37
-
 assay at Mus musculus
3.3.2.10 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.3.2.10 5.2 8.3 assay at pH 5.2, 7.4, and 8.3 Mus musculus
3.3.2.10 5.2 8.3 assay at pH 5.2, 7.4, and 8.3 Homo sapiens