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Literature summary extracted from

  • Perrino, C.; Naga Prasad, S.V.; Schroder, J.N.; Hata, J.A.; Milano, C.; Rockman, H.A.
    Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex (2005), Circulation, 111, 2579-2587.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.15 plasma membrane
-
 Mus musculus 5886
-
2.7.11.15 plasma membrane
-
 Sus scrofa 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor Sus scrofa
-
 ADP + phosphorylated beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor Mus musculus betaARK1 is responsible for desensitization and down regulation of beta-adrenergic receptors ADP + phosphorylated beta-adrenergic receptor
-
 ?
2.7.11.15 additional information Sus scrofa adenovirus-mediated overexpression of phosphoinositide 3-kinase restore contractile function of cardiac myocytes isolated from failing hearts, the recombinant PIK replaces the endogenous PIK in the transgenic pigs, the endogenous PIK shows abnormally increased activity in complex with betaARK1, overview ?
-
 ?
2.7.11.15 additional information Mus musculus betaARK1 binds phosphoinositide 3-kinase, which is by this way targeted to agonist-stimulated beta-adrenergic receptors, where it regulates endocytosis, disruption of the betaARK1-PIK complex leads to restoration of beta-adrenergic receptor signaling and contractile function in heart failure, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Mus musculus
-
-
-
2.7.11.15 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.15 heart
-
 Mus musculus
-
2.7.11.15 heart
-
 Sus scrofa
-
2.7.11.15 myocardium
-
 Mus musculus
-
2.7.11.15 myocardium
-
 Sus scrofa
-
2.7.11.15 myocyte cardiac myocytes isolated from failing hearts Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor
-
 Mus musculus ADP + phosphorylated beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor
-
 Sus scrofa ADP + phosphorylated beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor betaARK1 is responsible for desensitization and down regulation of beta-adrenergic receptors Mus musculus ADP + phosphorylated beta-adrenergic receptor
-
 ?
2.7.11.15 additional information adenovirus-mediated overexpression of phosphoinositide 3-kinase restore contractile function of cardiac myocytes isolated from failing hearts, the recombinant PIK replaces the endogenous PIK in the transgenic pigs, the endogenous PIK shows abnormally increased activity in complex with betaARK1, overview Sus scrofa ?
-
 ?
2.7.11.15 additional information betaARK1 binds phosphoinositide 3-kinase, which is by this way targeted to agonist-stimulated beta-adrenergic receptors, where it regulates endocytosis, disruption of the betaARK1-PIK complex leads to restoration of beta-adrenergic receptor signaling and contractile function in heart failure, overview Mus musculus ?
-
 ?
2.7.11.15 additional information betaARK1 interacts with recombinant phosphoinositide 3-kinase expressed in transgenic mice Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.15 betaARK1
-
 Mus musculus
2.7.11.15 betaARK1
-
 Sus scrofa
2.7.11.15 betabeta-adrenergic receptor kinase 1
-
 Mus musculus
2.7.11.15 betabeta-adrenergic receptor kinase 1
-
 Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.15 ATP
-
 Mus musculus
2.7.11.15 ATP
-
 Sus scrofa