EC Number | Application | Comment | Organism |
---|---|---|---|
5.6.2.2 | pharmacology | the enzyme is a target for anticancer drug development | Tequatrovirus T4 |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.6.2.2 | m-AMSA | hydrochloride salt of amsacrine, topoisomerase poison | Tequatrovirus T4 | |
5.6.2.2 | novobiocin | cumarin-based drug | Tequatrovirus T4 |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
5.6.2.2 | KCl | - |
Tequatrovirus T4 | |
5.6.2.2 | Mg2+ | - |
Tequatrovirus T4 |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.6.2.2 | additional information | Tequatrovirus T4 | increased expression of the enzyme causes neoplasia | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.6.2.2 | Tequatrovirus T4 | - |
- |
- |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
5.6.2.2 | additional information | - |
development and evaluation of a dual-color fluorescence cross-correlation spectroscopy in homogeneous solution for monitoring enzyme activity and inhibitory effect of compounds, overview | Tequatrovirus T4 |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.6.2.2 | dsDNA + ATP + H2O | cleavage and religation of dsDNA | Tequatrovirus T4 | ? | - |
? | |
5.6.2.2 | additional information | increased expression of the enzyme causes neoplasia | Tequatrovirus T4 | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.6.2.2 | Topoisomerase II | - |
Tequatrovirus T4 |
5.6.2.2 | type II DNA topoisomerase | - |
Tequatrovirus T4 |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
5.6.2.2 | 22 | - |
assay at room temperature | Tequatrovirus T4 |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
5.6.2.2 | 7.6 | - |
assay at | Tequatrovirus T4 |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
5.6.2.2 | ATP | - |
Tequatrovirus T4 |