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Literature summary extracted from

  • Xia, H.J.; Yang, G.
    Inositol 1,4,5-trisphosphate 3-kinases: functions and regulations (2005), Cell Res., 15, 83-91.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.127 12-O-tetradecanoyl phorbol 13-acetate stimulating in presence of cAMP Homo sapiens
2.7.1.127 12-O-tetradecanoyl phorbol 13-acetate stimulating in presence of cAMP Rattus norvegicus
2.7.1.127 Ca2+/CaM-dependent kinase II i.e. CaMKII, activates the enzyme by phosphorylation at a Thr residue Sus scrofa
2.7.1.127 Ca2+/CaM-dependent kinase II i.e. CaMKII, activates the enzyme by phosphorylation of Thr311 Homo sapiens
2.7.1.127 Ca2+/CaM-dependent kinase II i.e. CaMKII, activates the enzyme by phosphorylation of threonine residue Rattus norvegicus
2.7.1.127 Calmodulin 2-3fold activation of isozyme IP33K-A and 7-8fold of isozyme IP33K-B, in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids Homo sapiens
2.7.1.127 Calmodulin isozyme IP33K-A: 3-6fold activation in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids, residues Ser156-Leu189 and Trp165 are required Rattus norvegicus
2.7.1.127 Calmodulin up to 20fold activation in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids Sus scrofa
2.7.1.127 cAMP-dependent protein kinase i.e. PKA, activates the enzyme by phosphorylation at a Ser residue Sus scrofa
2.7.1.127 cAMP-dependent protein kinase i.e. PKA, activates the enzyme by phosphorylation at a serine residue Homo sapiens
2.7.1.127 cAMP-dependent protein kinase i.e. PKA, activates the enzyme by phosphorylation at Ser109, simultaneous phosphorylation at SEr109 and Ser175 inactivates the enzyme Rattus norvegicus
2.7.1.151 additional information no activation by calmodulin or Ca2+ Saccharomyces cerevisiae
2.7.1.151 additional information no activation by calmodulin or Ca2+ Arabidopsis thaliana

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.127 overexpression of enzyme D-IP3K1 leads to increased resistance of flies to H2O2, but not to paraquat-induced oxidative stress, due to a decreased 1D-myo-inositol 1,4,5-trisphosphate level Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.127 Protein kinase C negative regulatory function, phosphorylates the enzyme at a serine residue Homo sapiens
2.7.1.127 Protein kinase C negative regulatory function, phosphorylates the enzyme at Ser175, simultaneous phosphorylation at Ser109 and Ser175 also inactivates the enzyme Rattus norvegicus
2.7.1.127 Protein kinase C negative regulatory function, phosphorylates the enzyme at a Ser residue Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.127 cytoplasm isozyme IP33K-C Homo sapiens 5737
-
2.7.1.127 cytoskeleton isozymes IP33K-A and IP33K-B Homo sapiens 5856
-
2.7.1.127 endoplasmic reticulum isozyme IP33K-B Homo sapiens 5783
-
2.7.1.127 plasma membrane isozyme IP33K-B Homo sapiens 5886
-
2.7.1.151 nucleus
-
 Homo sapiens 5634
-
2.7.1.151 nucleus
-
 Saccharomyces cerevisiae 5634
-
2.7.1.151 nucleus
-
 Arabidopsis thaliana 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.127 Ca2+ activation by calmodulin in a Ca2+-dependent manner Homo sapiens
2.7.1.127 Ca2+ activation by calmodulin in a Ca2+-dependent manner Sus scrofa
2.7.1.127 Ca2+ isozyme IP33K-A: 3-6fold activation by calmodulin in a Ca2+-dependent manner Rattus norvegicus
2.7.1.127 Mg2+
-
 Drosophila melanogaster
2.7.1.127 Mg2+
-
 Homo sapiens
2.7.1.127 Mg2+
-
 Rattus norvegicus
2.7.1.127 Mg2+
-
 Sus scrofa
2.7.1.151 Mg2+
-
 Saccharomyces cerevisiae
2.7.1.151 Mg2+
-
 Arabidopsis thaliana

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.127 50000
-
 x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C Homo sapiens
2.7.1.127 50900
-
 x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C Rattus norvegicus
2.7.1.127 53500
-
 x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C Homo sapiens
2.7.1.127 74000
-
 x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C Rattus norvegicus
2.7.1.127 74500
-
 x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C Rattus norvegicus
2.7.1.127 75200
-
 x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Drosophila melanogaster the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Homo sapiens the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Sus scrofa the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 additional information Homo sapiens the enzyme might be involved in brain development, memory, and learning ?
-
 ?
2.7.1.127 additional information Rattus norvegicus the enzyme might be involved in brain development, memory, and learning ?
-
 ?
2.7.1.127 additional information Drosophila melanogaster the enzyme might be involved in oxidative damage resistance ?
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate Saccharomyces cerevisiae
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate Arabidopsis thaliana
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 ir
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate Saccharomyces cerevisiae
-
 ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 ir
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate Arabidopsis thaliana
-
 ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 ir
2.7.1.151 additional information Homo sapiens the enzyme is involved in the inositol phosphate metabolism which is important for several cellular functions and signaling, metabolism overview ?
-
 ?
2.7.1.151 additional information Saccharomyces cerevisiae the enzyme is involved in the inositol phosphate metabolism which is important for several cellular functions and signaling, metabolism overview ?
-
 ?
2.7.1.151 additional information Arabidopsis thaliana the enzyme is involved in the inositol phosphate metabolism which is important for several cellular functions and signaling, metabolism overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Drosophila melanogaster
-
-
-
2.7.1.127 Homo sapiens
-
 isozymes IP33K-A, IP33K-B, and IP33K-C
-
2.7.1.127 Rattus norvegicus
-
 isozymes IP33K-A, IP33K-B, and IP33K-C
-
2.7.1.127 Sus scrofa
-
-
-
2.7.1.151 Arabidopsis thaliana
-
 2 isozymes Ipk2alpha and Ipk2beta
-
2.7.1.151 Homo sapiens
-
-
-
2.7.1.151 Saccharomyces cerevisiae
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.127 phosphoprotein phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at a Ser residue, cAMP-dependent protein kinase activates the enzyme by phosphorylating a Ser residue, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of a Thr residue Sus scrofa
2.7.1.127 phosphoprotein phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at a serine residue, cAMP-dependent protein kinase activates the enzyme by phosphorylating at a serine residue, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of Thr311 Homo sapiens
2.7.1.127 phosphoprotein phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at Ser175, cAMP-dependent protein kinase activates the enzyme by phosphorylating Ser109, simultaneous phosphorylation at Ser109 and Ser175 also inactivates the enzyme, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of a Thr residue Rattus norvegicus
2.7.1.151 additional information the enzyme can be phosphorylated by protein kinase C in vitro Saccharomyces cerevisiae

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 brain
-
 Homo sapiens
-
2.7.1.127 brain
-
 Sus scrofa
-
2.7.1.127 brain isozymes IP33K-A, IP33K-B, and IP33K-C Rattus norvegicus
-
2.7.1.127 epithelium isozyme IP33K-C Rattus norvegicus
-
2.7.1.127 heart isozymes IP33K-B, and IP33K-C Rattus norvegicus
-
2.7.1.127 lung isozyme IP33K-B Rattus norvegicus
-
2.7.1.127 testis isozymes IP33K-A, IP33K-B, and IP33K-C Rattus norvegicus
-
2.7.1.127 thymus isozyme IP33K-B Rattus norvegicus
-
2.7.1.127 tongue isozyme IP33K-C Rattus norvegicus
-
2.7.1.151 flower isozymes Ipk2alpha and Ipk2beta Arabidopsis thaliana
-
2.7.1.151 leaf isozyme Ipk2alpha Arabidopsis thaliana
-
2.7.1.151 mesophyll isozyme Ipk2beta Arabidopsis thaliana
-
2.7.1.151 pollen isozyme Ipk2beta Arabidopsis thaliana
-
2.7.1.151 root isozymes Ipk2alpha and Ipk2beta Arabidopsis thaliana
-
2.7.1.151 silique isozyme Ipk2alpha Arabidopsis thaliana
-
2.7.1.151 stem isozyme Ipk2alpha Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Drosophila melanogaster ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Sus scrofa ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview Drosophila melanogaster ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview Homo sapiens ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview Sus scrofa ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 additional information the enzyme might be involved in brain development, memory, and learning Homo sapiens ?
-
 ?
2.7.1.127 additional information the enzyme might be involved in brain development, memory, and learning Rattus norvegicus ?
-
 ?
2.7.1.127 additional information the enzyme might be involved in oxidative damage resistance Drosophila melanogaster ?
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Saccharomyces cerevisiae ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Arabidopsis thaliana ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 ir
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Saccharomyces cerevisiae ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 ir
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Arabidopsis thaliana ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 ir
2.7.1.151 additional information the enzyme is involved in the inositol phosphate metabolism which is important for several cellular functions and signaling, metabolism overview Homo sapiens ?
-
 ?
2.7.1.151 additional information the enzyme is involved in the inositol phosphate metabolism which is important for several cellular functions and signaling, metabolism overview Saccharomyces cerevisiae ?
-
 ?
2.7.1.151 additional information the enzyme is involved in the inositol phosphate metabolism which is important for several cellular functions and signaling, metabolism overview Arabidopsis thaliana ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.127 ? x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C Homo sapiens
2.7.1.127 ? x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C Rattus norvegicus
2.7.1.127 More structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain Drosophila melanogaster
2.7.1.127 More structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain Homo sapiens
2.7.1.127 More structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain Sus scrofa
2.7.1.127 More structure analysis, the isozyme A contains a F-actin binding domain, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain Rattus norvegicus
2.7.1.151 More domain structure analysis, the enzyme contains an IP3-binding domain and an ATP/Mg2+ binding domain, but no F-actin-binding or CaM-binding domain, and no nucleus localization signal sequence Saccharomyces cerevisiae
2.7.1.151 More domain structure analysis, the enzyme contains an IP3-binding domain and an ATP/Mg2+ binding domain, but no F-actin-binding or CaM-binding domain, and no nucleus localization signal sequence Arabidopsis thaliana
2.7.1.151 More domain structure analysis, the enzyme contains an IP3-binding domain, a nucleus localization signal sequence, and an ATP/Mg2+ binding domain, but no F-actin-binding or CaM-binding domain Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.127 inositol 1,4,5-trisphosphate 3-kinase
-
 Drosophila melanogaster
2.7.1.127 inositol 1,4,5-trisphosphate 3-kinase
-
 Homo sapiens
2.7.1.127 inositol 1,4,5-trisphosphate 3-kinase
-
 Rattus norvegicus
2.7.1.127 inositol 1,4,5-trisphosphate 3-kinase
-
 Sus scrofa
2.7.1.127 IP3 3-kinase
-
 Drosophila melanogaster
2.7.1.127 IP3 3-kinase
-
 Homo sapiens
2.7.1.127 IP3 3-kinase
-
 Rattus norvegicus
2.7.1.127 IP3 3-kinase
-
 Sus scrofa
2.7.1.127 IP3K
-
 Drosophila melanogaster
2.7.1.127 IP3K
-
 Homo sapiens
2.7.1.127 IP3K
-
 Rattus norvegicus
2.7.1.127 IP3K
-
 Sus scrofa
2.7.1.151 Impk
-
 Homo sapiens
2.7.1.151 Impk
-
 Saccharomyces cerevisiae
2.7.1.151 Impk
-
 Arabidopsis thaliana
2.7.1.151 inositol 1,4,5-trisphosphate 3-kinase
-
 Saccharomyces cerevisiae
2.7.1.151 inositol 1,4,5-trisphosphate 3-kinase
-
 Arabidopsis thaliana
2.7.1.151 IP3 3-kinase
-
 Saccharomyces cerevisiae
2.7.1.151 IP3 3-kinase
-
 Arabidopsis thaliana
2.7.1.151 IP3K
-
 Saccharomyces cerevisiae
2.7.1.151 IP3K
-
 Arabidopsis thaliana
2.7.1.151 Ipk2
-
 Saccharomyces cerevisiae
2.7.1.151 Ipk2
-
 Arabidopsis thaliana
2.7.1.151 Ipk2/Impk/IP3K
-
 Saccharomyces cerevisiae
2.7.1.151 Ipk2/Impk/IP3K
-
 Arabidopsis thaliana
2.7.1.151 Ipk2beta/IP3K
-
 Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP
-
 Drosophila melanogaster
2.7.1.127 ATP
-
 Homo sapiens
2.7.1.127 ATP
-
 Rattus norvegicus
2.7.1.127 ATP
-
 Sus scrofa
2.7.1.151 ATP
-
 Homo sapiens
2.7.1.151 ATP
-
 Saccharomyces cerevisiae
2.7.1.151 ATP
-
 Arabidopsis thaliana