BRENDA - Enzyme Database show

Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice

Keith, R.L.; Miller, Y.E.; Hudish, T.M.; Girod, C.E.; Sotto-Santiago, S.; Franklin, W.A.; Nemenoff, R.A.; March, T.H.; Nana-Sinkam, S.P.; Geraci, M.W.; Cancer Res. 64, 5897-5904 (2004)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
5.3.99.4
medicine
manipulation of prostaglandin production distal to cyclooxygenase significantly reduces lung carcinogenesis in a tobacco smoke exposure model
Rattus norvegicus
Cloned(Commentary)
EC Number
Commentary
Organism
5.3.99.4
expression in alveolar and airway epithelial cells from Mus musculus
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Rattus norvegicus
-
Prostaglandin I2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.4
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
lung
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
661425
Rattus norvegicus
Prostaglandin I2
-
-
-
?
5.3.99.4
prostaglandin H2
-
661425
Rattus norvegicus
6-keto prostaglandin F1-alpha
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.4
medicine
manipulation of prostaglandin production distal to cyclooxygenase significantly reduces lung carcinogenesis in a tobacco smoke exposure model
Rattus norvegicus
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.4
expression in alveolar and airway epithelial cells from Mus musculus
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Rattus norvegicus
-
Prostaglandin I2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
lung
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
661425
Rattus norvegicus
Prostaglandin I2
-
-
-
?
5.3.99.4
prostaglandin H2
-
661425
Rattus norvegicus
6-keto prostaglandin F1-alpha
-
-
-
?