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Literature summary extracted from

  • Hasinoff, B.B.; Wu, X.; Begleiter, A.; Guziec, L.J.; Guziec, F.Jr.; Giorgianni, A.; Yang, S.; Jiang, Y.; Yalowich, J.C.
    Structure-activity study of the interaction of bioreductive benzoquinone alkylating agents with DNA topoisomerase II (2006), Cancer Chemother. Pharmacol., 57, 221-233.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.2.2 overexpression of isozyme IIalpha in Saccharomyces cerevisiae Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 1,4-hydroquinone inhibition mechanism Homo sapiens
5.6.2.2 benzoquinone alkylating agent, inhibits isozyme IIalpha via DNA cross-linking, forms cysteine sulfhydryl adducts, inhibits cell growth in vivo, which is 10fold increased in absence of cysteine, quantitative structure-activity analysis, structure of DNA binding, overview, inhibition mechanism Homo sapiens
5.6.2.2 benzoquinone mustard compounds induce the formation of DNA-protein complexes, quantitative structure-activity analysis, inhibition mechanism, overview Homo sapiens
5.6.2.2 EO9 inhibition mechanism Homo sapiens
5.6.2.2 etoposide
-
 Homo sapiens
5.6.2.2 menadione inhibition mechanism Homo sapiens
5.6.2.2 additional information IC50 values, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.2.2 nucleus
-
 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.2.2 KCl
-
 Homo sapiens
5.6.2.2 Mg2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Homo sapiens
-
 isozyme IIalpha
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.2.2 K-562 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 pBR322 DNA + ATP + H2O decatenation, relaxation and cleavage of pBR322 DNA Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 DNA topoisomerase II
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.6.2.2 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6.2.2 8
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
5.6.2.2 ATP required for decatenation activity Homo sapiens