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Literature summary extracted from

  • Stams, W.A.; den Boer, M.L.; Holleman, A.; Appel, I.M.; Beverloo, H.B.; van Wering, E.R.; Janka-Schaub, G.E.; Evans, W.E.; Pieters, R.
    Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia (2005), Blood, 105, 4223-4225.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.1.1 medicine the enzyme is widely used in chemotherapy for treatment of children with acute lymphoblastic leukemia, in vivo and in vitro resistance of the cells to the enzyme can occur Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.1 L-asparagine + H2O Homo sapiens
-
 L-aspartate + NH3
-
 ?
3.5.1.1 additional information Homo sapiens L-asparaginase is cytotoxic, resistance to L-asparaginase in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic cells is due to increased cellular expression of asparagine synthase, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.1 Homo sapiens
-
-
-
6.3.5.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.5.4 blood
-
 Homo sapiens
-
6.3.5.4 bone marrow
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.1 L-asparagine + H2O
-
 Homo sapiens L-aspartate + NH3
-
 ?
3.5.1.1 additional information L-asparaginase is cytotoxic, resistance to L-asparaginase in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic cells is due to increased cellular expression of asparagine synthase, overview Homo sapiens ?
-
 ?
6.3.5.4 ATP + L-Asp + L-Gln resistance to L-asparaginase and relapse risk are associated with high expression of asparagine synthetase in TEL-AML1-negative but not in TEL-AML1-positive B-lineage acute lymphoblastic leukemia Homo sapiens AMP + diphosphate + Asn + Glu
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.1 L-asparaginase
-
 Homo sapiens