EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.2.3 | acetate | as Na or K salt continues to activate at concentrations above 200 mM | Plasmodium falciparum |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.2.3 | expression in Escherichia coli | Plasmodium falciparum |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.7.2.3 | hanging-drop vapour-diffusion method, recombinant enzyme forms a hexagonal space group P6(1)22 with unit cell parameters a = b = 140.7 A, c = 263.9 A, 3.0 A resolution | Plasmodium falciparum |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.2.3 | KH2PO4 | above 50 mM | Plasmodium falciparum | |
2.7.2.3 | NaH2PO4 | above 50 mM | Plasmodium falciparum | |
2.7.2.3 | suramin | IC50: 0.007 mM | Plasmodium falciparum |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.2.3 | 0.52 | - |
3-phospho-D-glycerate | - |
Plasmodium falciparum | |
2.7.2.3 | 0.63 | - |
ATP | - |
Plasmodium falciparum |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.2.3 | Ca2+ | divalent metal ion required: Ca2+, Mg2+ or Mn2+. Mg2+ is the preferred cation | Plasmodium falciparum | |
2.7.2.3 | KCl | maximal activation at 100 mM | Plasmodium falciparum | |
2.7.2.3 | KH2PO4 | maximal activation at 25-50 mM | Plasmodium falciparum | |
2.7.2.3 | Mg2+ | divalent metal ion required: Ca2+, Mg2+ or Mn2+. Mg2+ is the preferred cation. Optimal concentration of Mg2+ is 5-15 mM | Plasmodium falciparum | |
2.7.2.3 | Mn2+ | divalent metal ion required: Ca2+, Mg2+ or Mn2+. Mg2+ is the preferred cation | Plasmodium falciparum | |
2.7.2.3 | NaCl | maximal activation at 100 mM | Plasmodium falciparum | |
2.7.2.3 | NaH2PO4 | maximal activation at 25-50 mM | Plasmodium falciparum |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.7.2.3 | 45000 | - |
x * 45000, SDS-PAGE | Plasmodium falciparum |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.2.3 | Plasmodium falciparum | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.2.3 | recombinant enzyme | Plasmodium falciparum |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.7.2.3 | 210 | - |
- |
Plasmodium falciparum |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.2.3 | ATP + 3-phospho-D-glycerate | - |
Plasmodium falciparum | ADP + 3-phospho-D-glyceroyl phosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.2.3 | ? | x * 45000, SDS-PAGE | Plasmodium falciparum |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.2.3 | 25 | - |
30 min, 27% loss of activity | Plasmodium falciparum |
2.7.2.3 | 37 | - |
30 min, nearly 80% loss of activity | Plasmodium falciparum |
2.7.2.3 | 49 | - |
30 min, approximately 95% loss of activity | Plasmodium falciparum |
2.7.2.3 | 61 | - |
30 min, enzyme retains less than 4% of its activity | Plasmodium falciparum |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.2.3 | 7.5 | 7.9 | - |
Plasmodium falciparum |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.2.3 | 0.007 | - |
IC50: 0.007 mM | Plasmodium falciparum | suramin |