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Literature summary extracted from

  • Prigge, S.T.; He, X.; Gerena, L.; Waters, N.C.; Reynolds, K.A.
    The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII (2003), Biochemistry, 42, 1160-1169.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.39 DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain BL21(DE3) Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.39 additional information Plasmodium falciparum enzyme is part of the malonyl-CoA-dependent type II fatty acid synthase complex in mitochondria, reaction sequence of the involved enzymes, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.39 Plasmodium falciparum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.39 recombinant enzyme from Escherichia coli by amylose affinity chromatography and gel filtration Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.39 malonyl-CoA + [acyl-carrier protein] type II [acyl-carrier protein] from Plasmodium falsiparum Plasmodium falciparum CoA + malonyl-[acyl-carrier protein]
-
 ?
2.3.1.39 additional information enzyme is part of the malonyl-CoA-dependent type II fatty acid synthase complex in mitochondria, reaction sequence of the involved enzymes, overview Plasmodium falciparum ?
-
 ?
2.3.1.39 additional information the beta-ketoacyl ACP synthase also catalyzes the reaction with low activity, overview, no activity with a recombinant type II [acyl-carrier protein] from Plasmodium falsiparum containing an N-terminal apicoplast transit peptide Plasmodium falciparum ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.39 malonyl-coenzyme A:ACP transacylase
-
 Plasmodium falciparum
2.3.1.39 MCAT
-
 Plasmodium falciparum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.39 37
-
 assay at Plasmodium falciparum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.39 7.2
-
 assay at Plasmodium falciparum