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Literature summary extracted from

  • Bellisola, G.; Fracasso, G.; Ippoliti, R.; Menestrina, G.; Rosen, A.; Solda, S.; Udali, S.; Tomazzolli, R.; Tridente, G.; Colombatti, M.
    Reductive activation of ricin and ricin A-chain immunotoxins by protein disulfide isomerase and thioredoxin reductase (2004), Biochem. Pharmacol., 67, 1721-1731.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.3.4.1 DTT the disulfide reduction activity of PDI-DTT is reduced Bos taurus
5.3.4.1 additional information thioredoxin reductase activates PDI at pH 7.4, 37°C involving glutathione reduction and NADPH, the disulfide reduction activity of PDI-thioredoxin reductase is reduced Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.4.1 endoplasmic reticulum
-
 Bos taurus 5783
-
5.3.4.1 membrane
-
 Bos taurus 16020
-
5.3.4.1 microsome
-
 Bos taurus
-
-

Organism

EC Number Organism UniProt Comment Textmining
5.3.4.1 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.4.1 commercial preparation liver enzyme Bos taurus
-
5.3.4.1 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.4.1 GSSG disulfide reduction of GSSG, the disulfide reduction activity of both PDI-thioredoxin reductase and PDI-DTT is reduced Bos taurus GSH
-
 ?
5.3.4.1 additional information PDI is a better thiol oxidant than a disulfide protein reductant Bos taurus ?
-
 ?
5.3.4.1 ricin reductive activation of ricin and ricin A-chain immunotoxins, assay system involving thioredoxin reductase and NADPH, overview Bos taurus ?
-
 ?
5.3.4.1 ricin A-chain immunotoxins reductive activation of ricin and ricin A-chain immunotoxins, assay system involving thioredoxin reductase and NADPH, overview Bos taurus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.4.1 PDI
-
 Bos taurus
5.3.4.1 protein disulfide isomerase
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.3.4.1 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.3.4.1 7.4
-
 assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
5.3.4.1 NADPH
-
 Bos taurus