BRENDA - Enzyme Database

The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase

Wang, X.; Song, K.S.; Guo, Q.X.; Tian, W.X.; Biochem. Pharmacol. 66, 2039-2047 (2003)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.85
(+)-catechin
50% inhibition of overall enzyme reaction at 1.6 mM, 50% inhibition of ketoacyl reduction reaction at 7.4 mM
Gallus gallus
2.3.1.85
(-)-epicatechin
50% inhibition of overall enzyme reaction at 3.8 mM, 50% inhibition of ketoacyl reduction reaction at 9.38 mM
Gallus gallus
2.3.1.85
(-)-epicatechin gallate
50% inhibition of overall enzyme reaction at 0.042 mM, 50% inhibition of ketoacyl reduction reaction at 0.068 mM, two-step inhibition mechanism with reversible initial inhibition and irreversible subsequent inactivation
Gallus gallus
2.3.1.85
(-)-epigallocatechin gallate
0.5 mM, 20% residual activity, 50% inhibition of overall enzyme reaction at 0.052 mM, 50% inhibition of ketoacyl reduction reaction at 0.1 mM
Gallus gallus
2.3.1.85
3,4-dihydroxybenzoic acid
50% inhibition of overall enzyme reaction at 9.0 mM, 50% inhibition of ketoacyl reduction reaction at 30 mM
Gallus gallus
2.3.1.85
catechol
50% inhibition of overall enzyme reaction at 7.4 mM, 50% inhibition of ketoacyl reduction reaction at 21 mM
Gallus gallus
2.3.1.85
gallic acid
50% inhibition of overall enzyme reaction at 21 mM, 50% inhibition of ketoacyl reduction reaction at 26 mM
Gallus gallus
2.3.1.85
propyl gallate
50% inhibition of overall enzyme reaction at 0.5 mM, 50% inhibition of ketoacyl reduction reaction at 1.4 mM
Gallus gallus
2.3.1.85
propyl p-hydroxylbenzoate
50% inhibition of overall enzyme reaction at 1.1 mM, 50% inhibition of ketoacyl reduction reaction at 2.6 mM
Gallus gallus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.85
Gallus gallus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.85
liver
-
Gallus gallus
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.85
(+)-catechin
50% inhibition of overall enzyme reaction at 1.6 mM, 50% inhibition of ketoacyl reduction reaction at 7.4 mM
Gallus gallus
2.3.1.85
(-)-epicatechin
50% inhibition of overall enzyme reaction at 3.8 mM, 50% inhibition of ketoacyl reduction reaction at 9.38 mM
Gallus gallus
2.3.1.85
(-)-epicatechin gallate
50% inhibition of overall enzyme reaction at 0.042 mM, 50% inhibition of ketoacyl reduction reaction at 0.068 mM, two-step inhibition mechanism with reversible initial inhibition and irreversible subsequent inactivation
Gallus gallus
2.3.1.85
(-)-epigallocatechin gallate
0.5 mM, 20% residual activity, 50% inhibition of overall enzyme reaction at 0.052 mM, 50% inhibition of ketoacyl reduction reaction at 0.1 mM
Gallus gallus
2.3.1.85
3,4-dihydroxybenzoic acid
50% inhibition of overall enzyme reaction at 9.0 mM, 50% inhibition of ketoacyl reduction reaction at 30 mM
Gallus gallus
2.3.1.85
catechol
50% inhibition of overall enzyme reaction at 7.4 mM, 50% inhibition of ketoacyl reduction reaction at 21 mM
Gallus gallus
2.3.1.85
gallic acid
50% inhibition of overall enzyme reaction at 21 mM, 50% inhibition of ketoacyl reduction reaction at 26 mM
Gallus gallus
2.3.1.85
propyl gallate
50% inhibition of overall enzyme reaction at 0.5 mM, 50% inhibition of ketoacyl reduction reaction at 1.4 mM
Gallus gallus
2.3.1.85
propyl p-hydroxylbenzoate
50% inhibition of overall enzyme reaction at 1.1 mM, 50% inhibition of ketoacyl reduction reaction at 2.6 mM
Gallus gallus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.85
liver
-
Gallus gallus
-