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Literature summary extracted from
- Cellular and molecular biology of prostacyclin synthase (2005), Biochem. Biophys. Res. Commun., 338, 45-52.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.4 | additional information | the extent of prostaglandin I2 production is determined by an appropriate ratio of COX-1/COX-2 to PGIS. Human vascular endothelial cells transfected with a construct that contains COX-1 and prostaglandin-I synthase cDNAs have an equivalent increase in COX-1 and PGIS, and produce a large quantity of prostaglandin-I synthase which is more than 200fold over that produced by untransfected cells | Homo sapiens |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 5.3.99.4 | medicine | overexpression of PGIS is highly effective in controlling vascular diseases and ischemia-reperfusion tissue injury, gene transfer of bicistronic COX-1/PGIS has the potential for treatment of diverse clinical disorders including vascular diseases, pulmonary hypertension, and ischemia-reperfusion cerebral and cardiac injury | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.3.99.4 | from endothelilal cells | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.4 | additional information | the enzyme is deactivated by prostaglandin H2 and peroxides | Bos taurus | |
| 5.3.99.4 | additional information | the enzyme is deactivated by prostaglandin H2 and peroxides | Homo sapiens | |
| 5.3.99.4 | peroxynitrite | inhibits PGIS activity by nitration of tyrosine 430 | Bos taurus |  |
| 5.3.99.4 | peroxynitrite | inhibits PGIS activity by nitration of Tyr 430 | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.3.99.4 | membrane | anchors to the membrane with a single N-terminal transmembrane domain, the bulk of the enzyme is located at the cytosolic side of ER | Mus musculus | 16020 | - |
| 5.3.99.4 | membrane | anchors to the membrane with a single N-terminal transmembrane domain, the bulk of the enzyme is located at the cytosolic side of ER | Homo sapiens | 16020 | - |
| 5.3.99.4 | membrane | anchors to the membrane with a single N-terminal transmembrane domain, the bulk of the enzyme is located at the cytosolic side of ER | Bos taurus | 16020 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.3.99.4 | 52000 | - |
- |
Bos taurus |
| 5.3.99.4 | 56000 | - |
- |
Homo sapiens |
| 5.3.99.4 | 56000 | - |
- |
Bos taurus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.4 | Prostaglandin H2 | Mus musculus | - |
Prostaglandin I2 | - |
? | |
| 5.3.99.4 | Prostaglandin H2 | Homo sapiens | - |
Prostaglandin I2 | - |
? | |
| 5.3.99.4 | Prostaglandin H2 | Bos taurus | - |
Prostaglandin I2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.99.4 | Bos taurus | - |
- |
- |
| 5.3.99.4 | Homo sapiens | - |
- |
- |
| 5.3.99.4 | Mus musculus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.3.99.4 | - |
Homo sapiens |
| 5.3.99.4 | - |
Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.3.99.4 | aorta | - |
Homo sapiens | - |
| 5.3.99.4 | aorta | - |
Bos taurus | - |
| 5.3.99.4 | blastocyst | - |
Mus musculus | - |
| 5.3.99.4 | blood platelet | microsomal fraction | Homo sapiens | - |
| 5.3.99.4 | blood platelet | microsomal fraction | Bos taurus | - |
| 5.3.99.4 | embryo | - |
Mus musculus | - |
| 5.3.99.4 | oviduct | - |
Mus musculus | - |
| 5.3.99.4 | oviduct | - |
Homo sapiens | - |
| 5.3.99.4 | vascular endothelial cell | - |
Mus musculus | - |
| 5.3.99.4 | vascular endothelial cell | - |
Homo sapiens | - |
| 5.3.99.4 | vascular endothelial cell | - |
Bos taurus | - |
| 5.3.99.4 | vascular smooth muscle cell | - |
Mus musculus | - |
| 5.3.99.4 | vascular smooth muscle cell | - |
Homo sapiens | - |
| 5.3.99.4 | vascular smooth muscle cell | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.4 | Prostaglandin H2 | - |
Mus musculus | Prostaglandin I2 | - |
? | |
| 5.3.99.4 | Prostaglandin H2 | - |
Homo sapiens | Prostaglandin I2 | - |
? | |
| 5.3.99.4 | Prostaglandin H2 | - |
Bos taurus | Prostaglandin I2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.99.4 | PGIS | - |
Mus musculus |
| 5.3.99.4 | PGIS | - |
Homo sapiens |
| 5.3.99.4 | PGIS | - |
Bos taurus |
| 5.3.99.4 | prostacyclin synthase | - |
Mus musculus |
| 5.3.99.4 | prostacyclin synthase | - |
Homo sapiens |
| 5.3.99.4 | prostacyclin synthase | - |
Bos taurus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.4 | heme | - |
Mus musculus | |
| 5.3.99.4 | heme | - |
Homo sapiens | |
| 5.3.99.4 | heme | - |
Bos taurus | |
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