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Literature summary extracted from

  • Yonezawa, Y.; Tsuzuki, T.; Eitsuka, T.; Miyazawa, T.; Hada, T.; Uryu, K.; Murakami-Nakai, C.; Ikawa, H.; Kuriyama, I.; Takemura, M.; Oshige, M.; Yoshida, H.; Sakaguchi, K.; Mizushina, Y.
    Inhibitory effect of conjugated eicosapentaenoic acid on human DNA topoisomerases I and II (2005), Arch. Biochem. Biophys., 435, 197-206.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 (4Z,7Z,10Z,13Z,16Z,19Z)-henicosa-4,7,10,13,16,19-hexaenoic acid IC50 is 0.05 mM for inhibition of decatenation of kinetoplast DNA Homo sapiens
5.6.2.2 (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid irreversible inhibition, IC50 is 0.01 mM for inhibition of decatenation of kinetoplast DNA, effects on thermal transition of dsDNA, overview Homo sapiens
5.6.2.2 conjugated docosahexanoic acid IC50 is 0.01 mM for inhibition of decatenation of kinetoplast DNA Homo sapiens
5.6.2.2 conjugated eicosapentaenoic acid irreversible inhibition, IC50 is 0.0025 mM for inhibition of decatenation of kinetoplast DNA, effects on thermal transition of dsDNA, overview Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.2.2 KCl
-
 Homo sapiens
5.6.2.2 Mg2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 kinetoplast DNA + ATP + H2O decatenation of kinetoplast DNA Homo sapiens ?
-
 ?
5.6.2.2 supercoiled pBR322 DNA cleavage of supercoiled pBR322 DNA Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 DNA topoisomerases II
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.6.2.2 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6.2.2 8
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
5.6.2.2 ATP
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.6.2.2 0.0025
-
 irreversible inhibition, IC50 is 0.0025 mM for inhibition of decatenation of kinetoplast DNA, effects on thermal transition of dsDNA, overview Homo sapiens conjugated eicosapentaenoic acid
5.6.2.2 0.01
-
 IC50 is 0.01 mM for inhibition of decatenation of kinetoplast DNA Homo sapiens conjugated docosahexanoic acid
5.6.2.2 0.01
-
 irreversible inhibition, IC50 is 0.01 mM for inhibition of decatenation of kinetoplast DNA, effects on thermal transition of dsDNA, overview Homo sapiens (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid
5.6.2.2 0.05
-
 IC50 is 0.05 mM for inhibition of decatenation of kinetoplast DNA Homo sapiens (4Z,7Z,10Z,13Z,16Z,19Z)-henicosa-4,7,10,13,16,19-hexaenoic acid