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Literature summary extracted from

  • Willemös, M.
    Competition between ammonia derived from internal glutamine hydrolysis and hydroxylamine present in the solution for incorporation into UTP as catalysed by Lactococcus lactis CTP synthase (2004), Arch. Biochem. Biophys., 424, 105-111.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.4.2 GTP stimulates reaction with ATP, UTP and Gln Lactococcus lactis

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.2 DL-DELTA1-pyrroline 5-carboxylate 0.125 mM, complete inhibition of ammonium chloride-dependent CTP synthesis Lactococcus lactis
6.3.4.2 Gln inhibition of hydroxylamine-dependent N4-OH CTP synthesis in presence of GTP Lactococcus lactis
6.3.4.2 GTP inhibition of N4-OH-CTP synthesis Lactococcus lactis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.2 0.259
-
Gln 30°C, pH 8.0 Lactococcus lactis

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.2 Lactococcus lactis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.2 ATP + UTP + Gln
-
Lactococcus lactis ADP + phosphate + CTP + Glu
-
?
6.3.4.2 ATP + UTP + hydroxylamine
-
Lactococcus lactis ADP + phosphate + N4-OH-CTP
-
?
6.3.4.2 ATP + UTP + NH4+
-
Lactococcus lactis ADP + phosphate + CTP
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.3.4.2 1.49
-
Gln 30°C, pH 8.0 Lactococcus lactis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.3.4.2 0.182
-
Gln 30°C, pH 8.0, inhibition of hydroxylamine-dependent N4-OH CTP synthesis in presence of GTP Lactococcus lactis
6.3.4.2 0.366
-
GTP 30°C, pH 8.0, inhibition of N4-OH-CTP synthesis Lactococcus lactis