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Literature summary extracted from

  • Kim, P.
    Current studies on biological tagatose production using L-arabinose isomerase: a review and future perspective (2004), Appl. Microbiol. Biotechnol., 65, 243-249.
    View publication on PubMed

Application

EC Number Application Comment Organism
5.3.1.4 additional information additionally, D-tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Geobacillus stearothermophilus
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Klebsiella aerogenes
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Lactobacillus gayonii
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Thermotoga neapolitana
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Thermus sp.
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Vibrio parahaemolyticus
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Yersinia pestis
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Shigella flexneri
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Bacillus subtilis
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Halalkalibacterium halodurans
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Oceanobacillus iheyensis
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Lactiplantibacillus plantarum
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Clostridium acetobutylicum
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Bifidobacterium longum
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Bacteroides thetaiotaomicron
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Escherichia coli
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Thermoanaerobacter mathranii
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Thermotoga maritima
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Salmonella enterica subsp. enterica serovar Typhi
5.3.1.4 additional information additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick Salmonella enterica subsp. enterica serovar Typhimurium
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Geobacillus stearothermophilus
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Klebsiella aerogenes
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Lactobacillus gayonii
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Thermotoga neapolitana
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Thermus sp.
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Vibrio parahaemolyticus
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Yersinia pestis
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Shigella flexneri
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Bacillus subtilis
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Halalkalibacterium halodurans
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Oceanobacillus iheyensis
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Lactiplantibacillus plantarum
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Clostridium acetobutylicum
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Bifidobacterium longum
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Bacteroides thetaiotaomicron
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Escherichia coli
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Thermoanaerobacter mathranii
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Thermotoga maritima
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Salmonella enterica subsp. enterica serovar Typhi
5.3.1.4 nutrition there has been industrial interest in the end product D-tagatose as a low-calorie sugar-substituting sweetener Salmonella enterica subsp. enterica serovar Typhimurium

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.1.4
-
Vibrio parahaemolyticus
5.3.1.4
-
Yersinia pestis
5.3.1.4
-
Shigella flexneri
5.3.1.4
-
Bacillus subtilis
5.3.1.4
-
Halalkalibacterium halodurans
5.3.1.4
-
Oceanobacillus iheyensis
5.3.1.4
-
Lactiplantibacillus plantarum
5.3.1.4
-
Clostridium acetobutylicum
5.3.1.4
-
Bifidobacterium longum
5.3.1.4
-
Bacteroides thetaiotaomicron
5.3.1.4
-
Thermotoga maritima
5.3.1.4
-
Salmonella enterica subsp. enterica serovar Typhi
5.3.1.4
-
Salmonella enterica subsp. enterica serovar Typhimurium
5.3.1.4 expression in Escherichia coli Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
5.3.1.4 additional information five point mutations increase the activity 11fold in the first round of evolution, and three point mutations in the second round of evolution increase the activity 5fold beyond the activity from the first round Geobacillus stearothermophilus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.3.1.4 Ca2+ serves as catalyst Geobacillus stearothermophilus
5.3.1.4 Ca2+ serves as catalyst Klebsiella aerogenes
5.3.1.4 Ca2+ serves as catalyst Lactobacillus gayonii
5.3.1.4 Ca2+ serves as catalyst Thermotoga neapolitana
5.3.1.4 Ca2+ serves as catalyst Thermus sp.
5.3.1.4 Ca2+ serves as catalyst Vibrio parahaemolyticus
5.3.1.4 Ca2+ serves as catalyst Yersinia pestis
5.3.1.4 Ca2+ serves as catalyst Shigella flexneri
5.3.1.4 Ca2+ serves as catalyst Bacillus subtilis
5.3.1.4 Ca2+ serves as catalyst Halalkalibacterium halodurans
5.3.1.4 Ca2+ serves as catalyst Oceanobacillus iheyensis
5.3.1.4 Ca2+ serves as catalyst Lactiplantibacillus plantarum
5.3.1.4 Ca2+ serves as catalyst Clostridium acetobutylicum
5.3.1.4 Ca2+ serves as catalyst Bifidobacterium longum
5.3.1.4 Ca2+ serves as catalyst Bacteroides thetaiotaomicron
5.3.1.4 Ca2+ serves as catalyst Escherichia coli
5.3.1.4 Ca2+ serves as catalyst Thermoanaerobacter mathranii
5.3.1.4 Ca2+ serves as catalyst Thermotoga maritima
5.3.1.4 Ca2+ serves as catalyst Salmonella enterica subsp. enterica serovar Typhi
5.3.1.4 Ca2+ serves as catalyst Salmonella enterica subsp. enterica serovar Typhimurium
5.3.1.4 Mn2+ activates the enzyme Klebsiella aerogenes
5.3.1.4 Mn2+ activates the enzyme Lactobacillus gayonii
5.3.1.4 Mn2+ activates the enzyme Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.1.4 60000
-
-
Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.1.4 D-galactose Geobacillus stearothermophilus
-
D-tagatose
-
?
5.3.1.4 D-galactose Klebsiella aerogenes
-
D-tagatose
-
?
5.3.1.4 D-galactose Lactobacillus gayonii
-
D-tagatose
-
?
5.3.1.4 D-galactose Thermotoga neapolitana
-
D-tagatose
-
?
5.3.1.4 D-galactose Thermus sp.
-
D-tagatose
-
?
5.3.1.4 D-galactose Vibrio parahaemolyticus
-
D-tagatose
-
?
5.3.1.4 D-galactose Yersinia pestis
-
D-tagatose
-
?
5.3.1.4 D-galactose Shigella flexneri
-
D-tagatose
-
?
5.3.1.4 D-galactose Bacillus subtilis
-
D-tagatose
-
?
5.3.1.4 D-galactose Halalkalibacterium halodurans
-
D-tagatose
-
?
5.3.1.4 D-galactose Oceanobacillus iheyensis
-
D-tagatose
-
?
5.3.1.4 D-galactose Lactiplantibacillus plantarum
-
D-tagatose
-
?
5.3.1.4 D-galactose Clostridium acetobutylicum
-
D-tagatose
-
?
5.3.1.4 D-galactose Bifidobacterium longum
-
D-tagatose
-
?
5.3.1.4 D-galactose Bacteroides thetaiotaomicron
-
D-tagatose
-
?
5.3.1.4 D-galactose Escherichia coli
-
D-tagatose
-
?
5.3.1.4 D-galactose Thermoanaerobacter mathranii
-
D-tagatose
-
?
5.3.1.4 D-galactose Thermotoga maritima
-
D-tagatose
-
?
5.3.1.4 D-galactose Salmonella enterica subsp. enterica serovar Typhi
-
D-tagatose
-
?
5.3.1.4 D-galactose Salmonella enterica subsp. enterica serovar Typhimurium
-
D-tagatose
-
?

Organism

EC Number Organism UniProt Comment Textmining
5.3.1.4 Bacillus subtilis P94523
-
-
5.3.1.4 Bacteroides thetaiotaomicron Q8AAW1
-
-
5.3.1.4 Bifidobacterium longum Q8G7J3
-
-
5.3.1.4 Clostridium acetobutylicum Q97JE0
-
-
5.3.1.4 Clostridium acetobutylicum Q97JE4
-
-
5.3.1.4 Escherichia coli P08202
-
-
5.3.1.4 Escherichia coli P58538
-
-
5.3.1.4 Escherichia coli Q8FL89
-
-
5.3.1.4 Geobacillus stearothermophilus
-
-
-
5.3.1.4 Halalkalibacterium halodurans Q9KBQ2
-
-
5.3.1.4 Klebsiella aerogenes
-
-
-
5.3.1.4 Lactiplantibacillus plantarum Q88S84
-
-
5.3.1.4 Lactobacillus gayonii
-
-
-
5.3.1.4 Oceanobacillus iheyensis Q8EMP4
-
-
5.3.1.4 Salmonella enterica subsp. enterica serovar Typhi P58539
-
-
5.3.1.4 Salmonella enterica subsp. enterica serovar Typhimurium P06189
-
-
5.3.1.4 Shigella flexneri Q7UDT4
-
-
5.3.1.4 Thermoanaerobacter mathranii
-
-
-
5.3.1.4 Thermotoga maritima Q9WYB3
-
-
5.3.1.4 Thermotoga neapolitana
-
-
-
5.3.1.4 Thermus sp.
-
-
-
5.3.1.4 Vibrio parahaemolyticus
-
-
-
5.3.1.4 Yersinia pestis P58540
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.1.4
-
Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.1.4 D-galactose
-
Geobacillus stearothermophilus D-tagatose
-
?
5.3.1.4 D-galactose
-
Klebsiella aerogenes D-tagatose
-
?
5.3.1.4 D-galactose
-
Lactobacillus gayonii D-tagatose
-
?
5.3.1.4 D-galactose
-
Thermotoga neapolitana D-tagatose
-
?
5.3.1.4 D-galactose
-
Thermus sp. D-tagatose
-
?
5.3.1.4 D-galactose
-
Vibrio parahaemolyticus D-tagatose
-
?
5.3.1.4 D-galactose
-
Yersinia pestis D-tagatose
-
?
5.3.1.4 D-galactose
-
Shigella flexneri D-tagatose
-
?
5.3.1.4 D-galactose
-
Bacillus subtilis D-tagatose
-
?
5.3.1.4 D-galactose
-
Halalkalibacterium halodurans D-tagatose
-
?
5.3.1.4 D-galactose
-
Oceanobacillus iheyensis D-tagatose
-
?
5.3.1.4 D-galactose
-
Lactiplantibacillus plantarum D-tagatose
-
?
5.3.1.4 D-galactose
-
Clostridium acetobutylicum D-tagatose
-
?
5.3.1.4 D-galactose
-
Bifidobacterium longum D-tagatose
-
?
5.3.1.4 D-galactose
-
Bacteroides thetaiotaomicron D-tagatose
-
?
5.3.1.4 D-galactose
-
Escherichia coli D-tagatose
-
?
5.3.1.4 D-galactose
-
Thermoanaerobacter mathranii D-tagatose
-
?
5.3.1.4 D-galactose
-
Thermotoga maritima D-tagatose
-
?
5.3.1.4 D-galactose
-
Salmonella enterica subsp. enterica serovar Typhi D-tagatose
-
?
5.3.1.4 D-galactose
-
Salmonella enterica subsp. enterica serovar Typhimurium D-tagatose
-
?

Subunits

EC Number Subunits Comment Organism
5.3.1.4 hexamer alpha6 Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
5.3.1.4 AI
-
Geobacillus stearothermophilus
5.3.1.4 AI
-
Klebsiella aerogenes
5.3.1.4 AI
-
Lactobacillus gayonii
5.3.1.4 AI
-
Thermotoga neapolitana
5.3.1.4 AI
-
Thermus sp.
5.3.1.4 AI
-
Vibrio parahaemolyticus
5.3.1.4 AI
-
Yersinia pestis
5.3.1.4 AI
-
Shigella flexneri
5.3.1.4 AI
-
Bacillus subtilis
5.3.1.4 AI
-
Halalkalibacterium halodurans
5.3.1.4 AI
-
Oceanobacillus iheyensis
5.3.1.4 AI
-
Lactiplantibacillus plantarum
5.3.1.4 AI
-
Clostridium acetobutylicum
5.3.1.4 AI
-
Bifidobacterium longum
5.3.1.4 AI
-
Bacteroides thetaiotaomicron
5.3.1.4 AI
-
Escherichia coli
5.3.1.4 AI
-
Thermoanaerobacter mathranii
5.3.1.4 AI
-
Thermotoga maritima
5.3.1.4 AI
-
Salmonella enterica subsp. enterica serovar Typhi
5.3.1.4 AI
-
Salmonella enterica subsp. enterica serovar Typhimurium
5.3.1.4 L-arabinose isomerase
-
Geobacillus stearothermophilus
5.3.1.4 L-arabinose isomerase
-
Klebsiella aerogenes
5.3.1.4 L-arabinose isomerase
-
Lactobacillus gayonii
5.3.1.4 L-arabinose isomerase
-
Thermotoga neapolitana
5.3.1.4 L-arabinose isomerase
-
Thermus sp.
5.3.1.4 L-arabinose isomerase
-
Vibrio parahaemolyticus
5.3.1.4 L-arabinose isomerase
-
Yersinia pestis
5.3.1.4 L-arabinose isomerase
-
Shigella flexneri
5.3.1.4 L-arabinose isomerase
-
Bacillus subtilis
5.3.1.4 L-arabinose isomerase
-
Halalkalibacterium halodurans
5.3.1.4 L-arabinose isomerase
-
Oceanobacillus iheyensis
5.3.1.4 L-arabinose isomerase
-
Lactiplantibacillus plantarum
5.3.1.4 L-arabinose isomerase
-
Bifidobacterium longum
5.3.1.4 L-arabinose isomerase
-
Bacteroides thetaiotaomicron
5.3.1.4 L-arabinose isomerase
-
Escherichia coli
5.3.1.4 L-arabinose isomerase
-
Thermoanaerobacter mathranii
5.3.1.4 L-arabinose isomerase
-
Thermotoga maritima
5.3.1.4 L-arabinose isomerase
-
Salmonella enterica subsp. enterica serovar Typhi
5.3.1.4 L-arabinose isomerase
-
Salmonella enterica subsp. enterica serovar Typhimurium
5.3.1.4 L-arabinose isomerase 1
-
Clostridium acetobutylicum
5.3.1.4 L-arabinose isomerase 2
-
Clostridium acetobutylicum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.3.1.4 7.5 8.5
-
Geobacillus stearothermophilus
5.3.1.4 7.5 8.5
-
Klebsiella aerogenes
5.3.1.4 7.5 8.5
-
Lactobacillus gayonii
5.3.1.4 7.5 8.5
-
Thermotoga neapolitana
5.3.1.4 7.5 8.5
-
Thermus sp.
5.3.1.4 7.5 8.5
-
Vibrio parahaemolyticus
5.3.1.4 7.5 8.5
-
Yersinia pestis
5.3.1.4 7.5 8.5
-
Shigella flexneri
5.3.1.4 7.5 8.5
-
Bacillus subtilis
5.3.1.4 7.5 8.5
-
Halalkalibacterium halodurans
5.3.1.4 7.5 8.5
-
Oceanobacillus iheyensis
5.3.1.4 7.5 8.5
-
Lactiplantibacillus plantarum
5.3.1.4 7.5 8.5
-
Clostridium acetobutylicum
5.3.1.4 7.5 8.5
-
Bifidobacterium longum
5.3.1.4 7.5 8.5
-
Bacteroides thetaiotaomicron
5.3.1.4 7.5 8.5
-
Escherichia coli
5.3.1.4 7.5 8.5
-
Thermoanaerobacter mathranii
5.3.1.4 7.5 8.5
-
Thermotoga maritima
5.3.1.4 7.5 8.5
-
Salmonella enterica subsp. enterica serovar Typhi
5.3.1.4 7.5 8.5
-
Salmonella enterica subsp. enterica serovar Typhimurium

pH Range

EC Number pH Minimum pH Maximum Comment Organism
5.3.1.4 7.5 8.5
-
Clostridium acetobutylicum
5.3.1.4 7.5 8.5
-
Escherichia coli