EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.10.1 | angiotensin II | induces transactivation of epidermal growth factor receptor, mechanism | Homo sapiens | |
2.7.10.1 | additional information | reactive oxygen species, such as O2.- and H2O2, function as mitogenic mediators of activated growth-factor-receptor signaling | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.10.1 | ebselen | - |
Bos taurus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.10.1 | membrane | transmembrane proteins with a single transmembrane pass, a cytoplasmic domain, and an extracellular domain, overview | Homo sapiens | 16020 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.10.1 | additional information | Homo sapiens | activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, such as O2.- and H2O2, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview | ? | - |
? | |
2.7.10.1 | additional information | Bos taurus | activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.10.1 | Bos taurus | - |
- |
- |
2.7.10.1 | Homo sapiens | - |
2 isozymes PDGF-alpha receptor and PDGF-beta receptor, 4 isozymes FGFR-1, FGFR-2, FGFR-3, and FGFR-4 | - |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.10.1 | glycoprotein | epidermal growth factor receptor contains a glycosylated extracellular domain | Homo sapiens |
2.7.10.1 | phosphoprotein | 7 autophosphorylation sites, specific binding sites for Src family protein kinases, in PDGF-beta receptor, epidermal growth factor receptor is autophosphorylated after ligand binding forming dimers or oligomers with itself or other members of the Erb family | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.10.1 | A-431 cell | epidermoid carcinoma | Homo sapiens | - |
2.7.10.1 | aorta | smooth muscle | Homo sapiens | - |
2.7.10.1 | chondrocyte | fibroblast growth factor receptor | Homo sapiens | - |
2.7.10.1 | endothelial cell | - |
Homo sapiens | - |
2.7.10.1 | fibroblast | lung | Homo sapiens | - |
2.7.10.1 | heart | vascular endothelial growth factor receptor | Homo sapiens | - |
2.7.10.1 | Hep-G2 cell | - |
Homo sapiens | - |
2.7.10.1 | lung | fibroblast | Homo sapiens | - |
2.7.10.1 | macrophage | - |
Homo sapiens | - |
2.7.10.1 | myocyte | tracheal | Bos taurus | - |
2.7.10.1 | neutrophil | - |
Homo sapiens | - |
2.7.10.1 | placenta | - |
Homo sapiens | - |
2.7.10.1 | smooth muscle | aortic | Homo sapiens | - |
2.7.10.1 | trachea | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.10.1 | additional information | activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, such as O2.- and H2O2, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview | Homo sapiens | ? | - |
? | |
2.7.10.1 | additional information | activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview | Bos taurus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.10.1 | dimer | platelet-derived growth factor receptor is a homo- or heterodimer wih A and B chains being assembled in different combinations, i.e. PDGF-alpha receptor or PDGF-beta receptor | Homo sapiens |
2.7.10.1 | monomer | epidermal growth factor receptor | Homo sapiens |
2.7.10.1 | oligomer | epidermal growth factor receptor is autophosphorylated after ligand binding forming dimers or oligomers with itself or other members of the Erb family | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.10.1 | Egfr | - |
Homo sapiens |
2.7.10.1 | ephrine receptor | - |
Homo sapiens |
2.7.10.1 | epidermal growth factor receptor | - |
Homo sapiens |
2.7.10.1 | FGFR | - |
Homo sapiens |
2.7.10.1 | fibroblast growth factor receptor | - |
Homo sapiens |
2.7.10.1 | hepatocyte growth factor receptor | - |
Homo sapiens |
2.7.10.1 | insulin receptor | - |
Homo sapiens |
2.7.10.1 | insulin-like growth factor receptor | - |
Homo sapiens |
2.7.10.1 | macrophage colony-stimulating factor receptor | - |
Homo sapiens |
2.7.10.1 | More | epidermal growth factor receptor is a member of the Erb family | Homo sapiens |
2.7.10.1 | nerve growth factor receptor | - |
Homo sapiens |
2.7.10.1 | PDGF-alpha receptor | - |
Homo sapiens |
2.7.10.1 | PDGF-beta receptor | - |
Homo sapiens |
2.7.10.1 | PDGFR | - |
Homo sapiens |
2.7.10.1 | PDGFR | - |
Bos taurus |
2.7.10.1 | platelet-derived growth factor receptor | - |
Homo sapiens |
2.7.10.1 | platelet-derived growth factor receptor | - |
Bos taurus |
2.7.10.1 | receptor tyrosine kinase | - |
Homo sapiens |
2.7.10.1 | RPTK | - |
Homo sapiens |
2.7.10.1 | vascular endothelial growth factor receptor | - |
Homo sapiens |
2.7.10.1 | VEGFR | - |
Homo sapiens |