BRENDA - Enzyme Database show

Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brain

Vazquez-Tello, A.; Fan, L.; Hou, X.; Joyal, J.S.; Mancini, J.A.; Quiniou, C.; Clyman, R.I.; Gobeil, F.Jr.; Varma, D.R.; Chemtob, S.; Am. J. Physiol. 287, R1155-R1163 (2004)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
5.3.99.3
glutathione
-
Rattus norvegicus
5.3.99.3
glutathione
-
Sus scrofa
Cloned(Commentary)
EC Number
Commentary
Organism
5.3.99.3
-
Homo sapiens
Engineering
EC Number
Amino acid exchange
Commentary
Organism
5.3.99.3
C-delta-35
35-amino acid COOH-terminal deletion, diminishes association of the enzyme with membranes
Rattus norvegicus
5.3.99.3
C-delta-35
35-amino acid COOH-terminal deletion, diminishes association of the enzyme with membranes
Sus scrofa
5.3.99.3
C58K
diminishes association of the enzyme with membranes
Rattus norvegicus
5.3.99.3
C58K
diminishes association of the enzyme with membranes
Sus scrofa
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.3
MK 886
inhibits microsomal PGE2
Rattus norvegicus
5.3.99.3
MK 886
inhibits microsomal PGE2
Sus scrofa
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
cytosol
-
Sus scrofa
5829
-
5.3.99.3
cytosol
-
Rattus norvegicus
5829
-
5.3.99.3
microsome
-
Sus scrofa
-
-
5.3.99.3
microsome
-
Rattus norvegicus
-
-
5.3.99.3
nucleus
-
Sus scrofa
5634
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
Homo sapiens
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
?
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
Rattus norvegicus
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
?
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
Sus scrofa
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.3
Homo sapiens
-
-
-
5.3.99.3
Rattus norvegicus
-
-
-
5.3.99.3
Sus scrofa
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
brain
-
Sus scrofa
-
5.3.99.3
brain
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
660669
Homo sapiens
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
?
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
660669
Rattus norvegicus
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
?
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
660669
Sus scrofa
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
?
5.3.99.3
Prostaglandin H2
-
660669
Homo sapiens
Prostaglandin E2
-
-
-
?
5.3.99.3
Prostaglandin H2
-
660669
Rattus norvegicus
Prostaglandin E2
-
-
-
?
5.3.99.3
Prostaglandin H2
-
660669
Sus scrofa
Prostaglandin E2
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
5.3.99.3
glutathione
-
Rattus norvegicus
5.3.99.3
glutathione
-
Sus scrofa
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.3
-
Homo sapiens
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
5.3.99.3
C-delta-35
35-amino acid COOH-terminal deletion, diminishes association of the enzyme with membranes
Rattus norvegicus
5.3.99.3
C-delta-35
35-amino acid COOH-terminal deletion, diminishes association of the enzyme with membranes
Sus scrofa
5.3.99.3
C58K
diminishes association of the enzyme with membranes
Rattus norvegicus
5.3.99.3
C58K
diminishes association of the enzyme with membranes
Sus scrofa
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.3
MK 886
inhibits microsomal PGE2
Rattus norvegicus
5.3.99.3
MK 886
inhibits microsomal PGE2
Sus scrofa
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
cytosol
-
Sus scrofa
5829
-
5.3.99.3
cytosol
-
Rattus norvegicus
5829
-
5.3.99.3
microsome
-
Sus scrofa
-
-
5.3.99.3
microsome
-
Rattus norvegicus
-
-
5.3.99.3
nucleus
-
Sus scrofa
5634
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
Homo sapiens
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
?
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
Rattus norvegicus
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
?
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
Sus scrofa
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
brain
-
Sus scrofa
-
5.3.99.3
brain
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
660669
Homo sapiens
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
?
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
660669
Rattus norvegicus
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
?
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
660669
Sus scrofa
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
?
5.3.99.3
Prostaglandin H2
-
660669
Homo sapiens
Prostaglandin E2
-
-
-
?
5.3.99.3
Prostaglandin H2
-
660669
Rattus norvegicus
Prostaglandin E2
-
-
-
?
5.3.99.3
Prostaglandin H2
-
660669
Sus scrofa
Prostaglandin E2
-
-
-
?