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Literature summary extracted from

  • Shepherd, P.R.
    Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues (2005), Acta Physiol. Scand., 183, 3-12.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.154 adipokines block insulin signalling via PI3K isozymes Homo sapiens
2.7.1.154 adipokines block insulin signalling via PI3K isozymes Mus musculus
2.7.1.154 Caffeine might inhibit the enzyme Homo sapiens
2.7.1.154 Caffeine might inhibit the enzyme Mus musculus
2.7.1.154 cytokines block insulin signalling via PI3K isozymes Homo sapiens
2.7.1.154 cytokines block insulin signalling via PI3K isozymes Mus musculus
2.7.1.154 additional information enzyme is regulated by several feedback inhibition possibilities in the insulin signalling pathway, overview Homo sapiens
2.7.1.154 additional information enzyme is regulated by several feedback inhibition possibilities in the insulin signalling pathway, overview Mus musculus
2.7.1.154 naringenin might inhibit the enzyme Homo sapiens
2.7.1.154 naringenin might inhibit the enzyme Mus musculus
2.7.1.154 Wortmannin class I isozyme inhibitor, isozyme PI3K-C2alpha is resistant to inhibition Homo sapiens
2.7.1.154 Wortmannin class I isozyme inhibitor, isozyme PI3K-C2alpha is resistant to inhibition Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.154 Mg2+
-
 Mus musculus
2.7.1.154 Mg2+
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.154 85000
-
 x * 110000, catalytic subunit, + x * 85000, catalytically inactive adaptor subunit Mus musculus
2.7.1.154 85000
-
 x * 110000, catalytic subunit, + x * 85000, catalytically inactive adaptor subunit Homo sapiens
2.7.1.154 110000
-
 x * 110000, catalytic subunit, + x * 85000, catalytically inactive adaptor subunit Mus musculus
2.7.1.154 110000
-
 x * 110000, catalytic subunit, + x * 85000, catalytically inactive adaptor subunit Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.154 ATP + phosphoinositides Mus musculus enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview ADP + ?
-
 ?
2.7.1.154 ATP + phosphoinositides Homo sapiens enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview ADP + ?
-
 ?
2.7.1.154 ATP + phosphoinositides Homo sapiens PI3K-C2alpha enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview ADP + ?
-
 ?
2.7.1.154 additional information Mus musculus enzyme regulation, overview ?
-
 ?
2.7.1.154 additional information Homo sapiens enzyme regulation, overview ?
-
 ?
2.7.1.154 additional information Homo sapiens PI3K-C2alpha enzyme regulation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.154 Homo sapiens O00443 PI3K-C2alpha
-
2.7.1.154 Homo sapiens PI3K-C2alpha O00443 PI3K-C2alpha
-
2.7.1.154 Mus musculus Q61194 isozyme PI3K-C2alpha
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.154 phosphoprotein the phosphorylated enzyme is inactive Mus musculus
2.7.1.154 phosphoprotein the phosphorylated enzyme is inactive Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.154 ATP + phosphoinositides enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview Mus musculus ADP + ?
-
 ?
2.7.1.154 ATP + phosphoinositides enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview Homo sapiens ADP + ?
-
 ?
2.7.1.154 ATP + phosphoinositides phosphorylation of the D-3 position on the inositol ring Mus musculus ADP + ?
-
 ?
2.7.1.154 ATP + phosphoinositides phosphorylation of the D-3 position on the inositol ring Homo sapiens ADP + ?
-
 ?
2.7.1.154 ATP + phosphoinositides enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview Homo sapiens PI3K-C2alpha ADP + ?
-
 ?
2.7.1.154 ATP + phosphoinositides phosphorylation of the D-3 position on the inositol ring Homo sapiens PI3K-C2alpha ADP + ?
-
 ?
2.7.1.154 additional information enzyme regulation, overview Mus musculus ?
-
 ?
2.7.1.154 additional information enzyme regulation, overview Homo sapiens ?
-
 ?
2.7.1.154 additional information enzyme regulation, overview Homo sapiens PI3K-C2alpha ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.154 ? x * 110000, catalytic subunit, + x * 85000, catalytically inactive adaptor subunit Mus musculus
2.7.1.154 ? x * 110000, catalytic subunit, + x * 85000, catalytically inactive adaptor subunit Homo sapiens
2.7.1.154 More domain structure of the adaptor subunit containing a SH3 domain and 2 SH2 domains, three different isozymes of the catalytically subunits P110alpha, P110beta, and P110gamma determine the 3 isozymes alpha, beta, gamma of the enzyme, all P110 subunits can interact with the p85 adaptor subunit Mus musculus
2.7.1.154 More domain structure of the adaptor subunit containing a SH3 domain and 2 SH2 domains, three different isozymes of the catalytically subunits P110alpha, P110beta, and P110gamma determine the 3 isozymes alpha, beta, gamma of the enzyme, all P110 subunits can interact with the p85 adaptor subunit Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.154 class-I PI 3-kinase
-
 Mus musculus
2.7.1.154 class-I PI 3-kinase
-
 Homo sapiens
2.7.1.154 class-II PI 3-kinase
-
 Mus musculus
2.7.1.154 class-II PI 3-kinase
-
 Homo sapiens
2.7.1.154 PI3K-C2alpha
-
 Mus musculus
2.7.1.154 PI3K-C2alpha
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.154 ATP
-
 Mus musculus
2.7.1.154 ATP
-
 Homo sapiens