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Literature summary extracted from

  • Eliot, A.C.; Kirsch, J.F.
    Avoiding the road less traveled: how the topology of enzyme-substrate complexes can dictate product selection (2003), Acc. Chem. Res., 36, 757-765.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.62 additional information no inhibition by the (R,S)-diastereomer of S-adenosyl-L-methionine Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.62 additional information
-
 additional information kinetics, first-order rate constant for the first half-reaction at saturation, the transamination reaction passes slowly due to either ketimine formation or its hydrolysis being hindered Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate Escherichia coli second of 4 steps in the biosynthesis of vitamin H, i.e. biotin S-adenosyl-4-methylthio-2-oxobutanoate + (7S,8R)-diaminononanoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.62 Escherichia coli
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate reaction mechanism analysis, via a enzyme-pyridoxamine phosphate, a S-adenosyl-L-methionine quinonoid intermediate, the substrate structure is a major determinant of the thermodynamic and/or kinetic accessibility of the quinonoid and ketimine intermediates Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.62 (S,S)-S-adenosyl-L-methionine + 8-amino-7-oxononanoate first half-reaction is reversible, the second one is irreversible, enzyme does not react with the (R,S)-diastereomer of S-adenosyl-L-methionine Escherichia coli S-adenosyl-4-methylthio-2-oxobutanoate + (7S,8R)-diaminononanoate i.e. 7,8-diaminopelargonic acid ?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate second of 4 steps in the biosynthesis of vitamin H, i.e. biotin Escherichia coli S-adenosyl-4-methylthio-2-oxobutanoate + (7S,8R)-diaminononanoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.62 7,8-diaminopelargonic acid synthase
-
 Escherichia coli
2.6.1.62 DAPA synthase
-
 Escherichia coli
2.6.1.62 More the enzyme is a member of fold type I PLP enzyme group, aminotransferase subclass II Escherichia coli

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.6.1.62 0.02
-
 S-adenosyl-L-methionine
-
 Escherichia coli
2.6.1.62 0.8
-
 8-Amino-7-oxononanoate
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.62 pyridoxal 5'-phosphate dependent on Escherichia coli